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- Luts, LLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups (author)
Peptide-containing nerve fibres in normal human parathyroid glands and in human parathyroid adenomas
- Article/chapterEnglish1995
Publisher, publication year, extent ...
- Oxford University Press (OUP),1995
- 9 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:0716f279-13e0-4724-8b56-6d43ea1bd50d
- https://lup.lub.lu.se/record/0716f279-13e0-4724-8b56-6d43ea1bd50dURI
- https://doi.org/10.1530/eje.0.1330543DOI
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- Language:English
- Summary in:English
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- There are only a few studies on the innervation of the human parathyroid glands and the content of neurotransmitters. We therefore studied the occurrence and distribution of peptide-containing and adrenergic nerve fibres and the coexistence pattern of neuromessengers by immunocytochemistry in normal (unaffected) and adenomatous parathyroid glands from patients undergoing surgery for parathyroid adenoma. The unaffected parathyroid glands had a moderate-to-rich supply of nerve fibres and terminals containing two general neuronal markers, protein gene product 9.5 (PGP 9.5) and synaptophysin, neuropeptide Y (NPY) and tyrosine hydroxylase (TH). They were seen close to blood vessels and, occasionally, among the endocrine cells. Only a few nerves contained calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), substance P (SP) and pituitary adenylate cyclase-activating peptide (PACAP). The general density of innervation, using PGP 9.5 and synaptophysin as markers, varied greatly among the different adenomas examined. This applied also to the density of fibres and terminals containing specific types of messengers. Some of the tumours had a rich supply of TH- and NPY-containing nerve fibres, while others contained only few scattered fibres. The CGRP-containing fibres varied from moderate in number to no detectable fibres. The PACAP-, SP- and VIP-containing fibres were always very few or not detectable. It is not inconceivable that the wide variation in general density of the innervation and frequency of peptide-containing nerves among individual parathyroid adenomas is of significance for their hormone secretory behaviour.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- Adenoma
- Calcitonin Gene-Related Peptide
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Nerve Fibers
- Neuropeptides
- Parathyroid Glands
- Parathyroid Neoplasms
- Pituitary Adenylate Cyclase-Activating Polypeptide
- Substance P
- Synaptophysin
- Thiolester Hydrolases
- Tyrosine 3-Monooxygenase
- Ubiquitin Thiolesterase
- Vasoactive Intestinal Peptide
Added entries (persons, corporate bodies, meetings, titles ...)
- Bergenfelz, ALund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kir-abe (author)
- Alumets, JLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-jal (author)
- Sundler, FLund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups(Swepub:lu)mphy-fsu (author)
- Patologi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:European Journal of Endocrinology: Oxford University Press (OUP)133:5, s. 51-5430804-46431479-683X
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