onr:"swepub:oai:lup.lub.lu.se:075112a5-4de4-458a-a45f-fc18a6df65a5"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04962naa a2200445 4500 | |
| 001 | oai:lup.lub.lu.se:075112a5-4de4-458a-a45f-fc18a6df65a5 | |
| 003 | SwePub | |
| 008 | 230919s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/075112a5-4de4-458a-a45f-fc18a6df65a52 URI |
| 024 | 7 | a https://doi.org/10.1002/mds.293012 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Espa, Elenau Lund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups4 aut0 (Swepub:lu)el8073es |
| 245 | 1 0 | a Dopamine Agonist Cotreatment Alters Neuroplasticity and Pharmacology of Levodopa-Induced Dyskinesia |
| 264 | c 2023-01-19 | |
| 264 | 1 | b Wiley,c 2023 |
| 520 | a BACKGROUND: Current models of levodopa (L-dopa)-induced dyskinesia (LID) are obtained by treating dopamine-depleted animals with L-dopa. However, patients with LID receive combination therapies that often include dopamine agonists.OBJECTIVE: Using 6-hydroxydopamine-lesioned rats as a model, we aimed to establish whether an adjunct treatment with the D2/3 agonist ropinirole impacts on patterns of LID-related neuroplasticity and drug responses.METHODS: Different regimens of L-dopa monotreatment and L-dopa-ropinirole cotreatment were compared using measures of hypokinesia and dyskinesia. Striatal expression of ∆FosB and angiogenesis markers were studied immunohistochemically. Antidyskinetic effects of different drug categories were investigated in parallel groups of rats receiving either L-dopa monotreatment or L-dopa combined with ropinirole.RESULTS: We defined chronic regimens of L-dopa monotreatment and L-dopa-ropinirole cotreatment inducing overall similar abnormal involuntary movement scores. Compared with the monotreatment group, animals receiving the L-dopa-ropinirole combination exhibited an overall lower striatal expression of ∆FosB with a distinctive compartmental distribution. The expression of angiogenesis markers and blood-brain barrier hyperpermeability was markedly reduced after L-dopa-ropinirole cotreatment compared with L-dopa monotreatment. Moreover, significant group differences were detected upon examining the response to candidate antidyskinetic drugs. In particular, compounds modulating D1 receptor signaling had a stronger effect in the L-dopa-only group, whereas both amantadine and the selective NMDA antagonist MK801 produced a markedly larger antidyskinetic effect in L-dopa-ropinirole cotreated animals.CONCLUSIONS: Cotreatment with ropinirole altered LID-related neuroplasticity and pharmacological response profiles. The impact of adjuvant dopamine agonist treatment should be taken into consideration when investigating LID mechanisms and candidate interventions in both clinical and experimental settings. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a Rats | |
| 653 | a Animals | |
| 653 | a Levodopa/therapeutic use | |
| 653 | a Dopamine Agonists/pharmacology | |
| 653 | a Antiparkinson Agents/therapeutic use | |
| 653 | a Rats, Sprague-Dawley | |
| 653 | a Dyskinesia, Drug-Induced/drug therapy | |
| 653 | a Oxidopamine | |
| 653 | a Disease Models, Animal | |
| 700 | 1 | a Song, Luu Xinhua Hospital4 aut0 (Swepub:lu)lu0276so |
| 700 | 1 | a Skovgård, Katrineu Lund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups4 aut0 (Swepub:lu)ka7183sk |
| 700 | 1 | a Fanni, Silviau Lund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups4 aut0 (Swepub:lu)si7134fa |
| 700 | 1 | a Cenci, M Angelau Lund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,LU profilområde: Naturlig och artificiell kognition,Lunds universitets profilområden,Basal Ganglia Pathophysiology,Lund University Research Groups,LU Profile Area: Natural and Artificial Cognition,Lund University Profile areas4 aut0 (Swepub:lu)mphy-ace |
| 710 | 2 | a Basala gangliernas patofysiologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Movement Disordersd : Wileyg 38:3, s. 410-422q 38:3<410-422x 0885-3185x 1531-8257 |
| 856 | 4 | u http://dx.doi.org/10.1002/mds.29301x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/075112a5-4de4-458a-a45f-fc18a6df65a5 |
| 856 | 4 8 | u https://doi.org/10.1002/mds.29301 |
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