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Detailed gene dose ...
Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia
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- Ivanov Öfverholm, Ingegerd (author)
- Karolinska Institutet
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- Tran, Anh Nhi (author)
- Karolinska Institutet
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- Olsson, Linda (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
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- Zachariadis, Vasilios (author)
- Karolinska Institutet
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- Heyman, Mats (author)
- Karolinska Institutet
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- Rudd, Eva (author)
- Karolinska Institutet
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- Syk Lundberg, Elisabeth (author)
- Karolinska Institutet
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- Nordenskjöld, Magnus (author)
- Karolinska Institutet
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- Johansson, Bertil (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Regional Laboratories Region Skåne
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- Nordgren, Ann (author)
- Karolinska Institutet
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- Barbany, Gisela (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2016-04-19
- 2016
- English 10 s.
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In: Leukemia & Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 57:9, s. 2161-2170
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Abstract
Subject headings
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- To identify copy number alterations (CNAs) in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL), array comparative genomic hybridization was performed on 50 cases; detected CNAs were validated in a cohort of 191 cases analyzed by single nucleotide polymorphism arrays. Apart from CNAs involving leukemia-associated genes, recurrent deletions targeting genes not previously implicated in BCP ALL, e.g. INIP, IRF1 and PDE4B, were identified. Deletions of the DNA repair gene INIP were exclusively found in cases with t(12;21), and deletions of SH2B3 were associated with intrachromosomal amplification of chromosome 21 (p
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- B-Other
- CNA
- copy number
- deletion
- pediatric ALL
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Ivanov Öfverholm ...
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Tran, Anh Nhi
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Olsson, Linda
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Zachariadis, Vas ...
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Heyman, Mats
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Rudd, Eva
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show more...
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Syk Lundberg, El ...
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Nordenskjöld, Ma ...
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Johansson, Berti ...
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Nordgren, Ann
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Barbany, Gisela
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Leukemia & Lymph ...
- By the university
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Lund University
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Karolinska Institutet