SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:07c0e6b9-31b9-42e2-81e6-4b124fee5478"
 

Search: onr:"swepub:oai:lup.lub.lu.se:07c0e6b9-31b9-42e2-81e6-4b124fee5478" > Nurr1 Is Required f...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Kadkhodaei, Banafsheh (author)

Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:07c0e6b9-31b9-42e2-81e6-4b124fee5478
  • https://lup.lub.lu.se/record/1532277URI
  • https://doi.org/10.1523/JNEUROSCI.3910-09.2009DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119766314URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Transcription factors involved in the specification and differentiation of neurons often continue to be expressed in the adult brain, but remarkably little is known about their late functions. Nurr1, one such transcription factor, is essential for early differentiation of midbrain dopamine (mDA) neurons but continues to be expressed into adulthood. In Parkinson's disease, Nurr1 expression is diminished and mutations in the Nurr1 gene have been identified in rare cases of disease; however, the significance of these observations remains unclear. Here, a mouse strain for conditional targeting of the Nurr1 gene was generated, and Nurr1 was ablated either at late stages of mDA neuron development by crossing with mice carrying Cre under control of the dopamine transporter locus or in the adult brain by transduction of adeno-associated virus Cre-encoding vectors. Nurr1 deficiency in maturing mDA neurons resulted in rapid loss of striatal DA, loss of mDA neuron markers, and neuron degeneration. In contrast, a more slowly progressing loss of striatal DA and mDA neuron markers was observed after ablation in the adult brain. As in Parkinson's disease, neurons of the substantia nigra compacta were more vulnerable than cells in the ventral tegmental area when Nurr1 was ablated at late embryogenesis. The results show that developmental pathways play key roles for the maintenance of terminally differentiated neurons and suggest that disrupted function of Nurr1 and other developmental transcription factors may contribute to neurodegenerative disease.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ito, Takehito (author)
  • Joodmardi, Eliza (author)
  • Mattsson, BengtLund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups(Swepub:lu)neur-bma (author)
  • Rouillard, Claude (author)
  • Carta, ManoloLund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine(Swepub:lu)med-mca (author)
  • Muramatsu, Shin-Ichi (author)
  • Sumi-Ichinose, Chiho (author)
  • Nomura, Takahide (author)
  • Metzger, Daniel (author)
  • Chambon, Pierre (author)
  • Lindqvist, Eva (author)
  • Larsson, Nils-GoeranKarolinska Institutet (author)
  • Olson, LarsKarolinska Institutet (author)
  • Björklund, AndersLund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups(Swepub:lu)mphy-abj (author)
  • Ichinose, Hiroshi (author)
  • Perlmann, ThomasKarolinska Institutet (author)
  • NeurobiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:The Journal of Neuroscience29:50, s. 15923-159321529-2401

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view