Search: onr:"swepub:oai:lup.lub.lu.se:08668048-1b96-44d3-8a50-9da4361b3536" >
Real-time PCR-assay...
Real-time PCR-assay in the delivery suite for determination of group B streptococcal colonization in a setting with risk-based antibiotic prophylaxis
-
- Håkansson, Stellan (author)
- Umeå universitet,Pediatrik
-
- Källén, Karin (author)
- Karolinska Institutet,Lund University,Lunds universitet,Tornbladinstitutet,Forskargrupper vid Lunds universitet,Tornblad Institute,Lund University Research Groups
-
Bullarbo, Maria (author)
-
show more...
-
- Holmgren, Per-Åke (author)
- Umeå universitet,Obstetrik och gynekologi
-
Bremme, Katarina (author)
-
- Larsson, Asa (author)
- Umeå universitet,Obstetrik och gynekologi
-
Norman, Margareta (author)
-
Noren, Hakan (author)
-
Ortmark-Wrede, Catharina (author)
-
Pettersson, Karin (author)
-
- Saltvedt, Sissel (author)
- Karolinska Institutet
-
- Sondell, Birgitta (author)
- Umeå universitet,Obstetrik och gynekologi
-
Tokarska, Magdalena (author)
-
von Vultee, Anna (author)
-
Jacobsson, Bo (author)
-
show less...
-
(creator_code:org_t)
- 2013-07-18
- 2014
- English.
-
In: Journal of Maternal-Fetal & Neonatal Medicine. - : Informa UK Limited. - 1476-7058 .- 1476-4954. ; 27:4, s. 328-332
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Objective: Intrapartum antibiotic prophylaxis (IAP) reduces the incidence of neonatal early onset group B streptococcal infections. The present study investigated if an automated PCR-assay, used bedside by the labor ward personnel was manageable and could decrease the use of IAP in a setting with a risk-based IAP strategy. Methods: The study comprises two phases. Phase 1 was a multicenter, randomized, controlled trial. Women with selected risk-factors were allocated either to PCR-IAP (prophylaxis given if positive or indeterminate) or IAP. A vaginal/rectal swab and superficial swabs from the neonate for conventional culture were also obtained. Phase 2 was non-randomized, assessing an improved version of the assay. Results: Phase 1 included 112 women in the PCR-IAP group and 117 in the IAP group. Excluding indeterminate results, the assay showed a sensitivity of 89% and a specificity of 90%. In 44 % of the PCR assays the result was indeterminate. The use of IAP was lower in the PCR group (53 versus 92%). Phase 2 included 94 women. The proportion of indeterminate results was reduced (15%). The GBS colonization rate was 31%. Conclusion: The PCR assay, in the hands of labor ward personnel, can be useful for selection of women to which IAP should be offered.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Antibiotics
- delivery
- prophylaxis
- real-time PCR
- S. agalactiae
- Antibiotics
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Håkansson, Stell ...
-
Källén, Karin
-
Bullarbo, Maria
-
Holmgren, Per-Åk ...
-
Bremme, Katarina
-
Larsson, Asa
-
show more...
-
Norman, Margaret ...
-
Noren, Hakan
-
Ortmark-Wrede, C ...
-
Pettersson, Kari ...
-
Saltvedt, Sissel
-
Sondell, Birgitt ...
-
Tokarska, Magdal ...
-
von Vultee, Anna
-
Jacobsson, Bo
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
Journal of Mater ...
- By the university
-
Lund University
-
Karolinska Institutet
-
Umeå University