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The earliest thymic...
The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.
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- Luc, Sidinh (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Luis, Tiago C (author)
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Boukarabila, Hanane (author)
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Macaulay, Iain C (author)
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- Buza-Vidas, Natalija (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Bouriez-Jones, Tiphaine (author)
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Lutteropp, Michael (author)
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Woll, Petter S (author)
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Loughran, Stephen J (author)
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Mead, Adam J (author)
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- Hultquist, Anne (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Brown, John (author)
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Mizukami, Takuo (author)
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Matsuoka, Sahoko (author)
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Ferry, Helen (author)
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Anderson, Kristina (author)
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Duarte, Sara (author)
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Atkinson, Deborah (author)
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- Soneji, Shamit (author)
- Karolinska Institutet
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Domanski, Aniela (author)
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Farley, Alison (author)
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Sanjuan-Pla, Alejandra (author)
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Carella, Cintia (author)
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Patient, Roger (author)
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de Bruijn, Marella (author)
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Enver, Tariq (author)
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Nerlov, Claus (author)
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Blackburn, Clare (author)
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Godin, Isabelle (author)
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- Jacobsen, Sten Eirik W (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- 2012-02-19
- 2012
- English.
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In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 13:4, s. 412-419
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Abstract
Subject headings
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- The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. These potentials were identical to those of candidate thymus-seeding progenitors in the bone marrow, which were closely related at the molecular level. Our findings establish the distinct lineage-restriction stage at which the T cell lineage-commitment process transits from the bone marrow to the remote thymus.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Luc, Sidinh
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Luis, Tiago C
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Boukarabila, Han ...
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Macaulay, Iain C
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Buza-Vidas, Nata ...
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Bouriez-Jones, T ...
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show more...
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Lutteropp, Micha ...
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Woll, Petter S
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Loughran, Stephe ...
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Mead, Adam J
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Hultquist, Anne
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Brown, John
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Mizukami, Takuo
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Matsuoka, Sahoko
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Ferry, Helen
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Anderson, Kristi ...
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Duarte, Sara
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Atkinson, Debora ...
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Soneji, Shamit
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Domanski, Aniela
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Farley, Alison
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Sanjuan-Pla, Ale ...
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Carella, Cintia
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Patient, Roger
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de Bruijn, Marel ...
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Enver, Tariq
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Nerlov, Claus
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Blackburn, Clare
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Godin, Isabelle
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Jacobsen, Sten E ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Nature Immunolog ...
- By the university
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Lund University
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Karolinska Institutet