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Prevalence and char...
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Krishnan, Jerry A.University of Illinois at Chicago
(author)
Prevalence and characteristics of asthma-chronic obstructive pulmonary disease overlap in routine primary care practices
- Article/chapterEnglish2019
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LIBRIS-ID:oai:lup.lub.lu.se:08fabc99-4d7f-4ecb-97c3-4c56e49797e5
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https://lup.lub.lu.se/record/08fabc99-4d7f-4ecb-97c3-4c56e49797e5URI
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https://doi.org/10.1513/AnnalsATS.201809-607OCDOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Rationale: Adults may exhibit characteristics of both asthma and chronic obstructive pulmonary disease (COPD), a situation recently described as asthma-COPD overlap (ACO). There is a paucity of information about ACO in primary care. Objectives: To estimate the prevalence and describe characteristics of individuals withACOin primary care practices among patients currently diagnosed with asthma, COPD, or both; and to compare the prevalence and characteristics of ACO among the three source populations. Methods: The Respiratory Effectiveness Group conducted a crosssectional study of individuals ≥40 years old and with ≥2 outpatient primary care visits over a 2-year period in theUKOptimum Patient Care Research Database. Patients were classified into one of three source populations based on diagnostic codes: 1) COPD only, 2) both asthma and COPD, or 3) asthma only.ACOwas defined as the presence of all of the following 1) age ≥40 years, 2) current or former smoking, 3) postbronchodilator airflow limitation (forced expiratory volume in 1 second/ forced vital capacity <0.7), and 4) ≥12% and ≥200 ml reversibility in post-bronchodilator forced expiratory volume in 1 second. Results: Among 2,165 individuals (1,015 COPD only, 395 with both asthma and COPD, and 755 asthma only), the overall prevalence of ACO was 20% (95% confidence interval, 18-23%). Patients with ACO had a mean age of 70 years (standard deviation, 11 yr), 60% were men, 73% were former smokers (the rest were current smokers), and 66% were overweight or obese. Comorbid conditions were common in patients with ACO, including diabetes (53%), cardiovascular disease (36%), hypertension (30%), eczema (23%), and rhinitis (21%). The prevalence of ACO was higher in patients with a diagnosis of both asthma and COPD (32%) compared with a diagnosis of COPD only (20%; P<0.001) or asthma only (14%; P<0.001). Demographic and clinical characteristics of ACO varied across these three source populations. Conclusions: One in five individuals with a diagnosis of COPD, asthma, or both asthma and COPD in primary care settings have ACO based on the Respiratory Effectiveness Group ACO Working group criteria. The prevalence and characteristics of patients with ACO varies across the three source populations.
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Nibber, AnjanUniversity of Oxford
(author)
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Chisholm, AlisonRespiratory Effectiveness Group
(author)
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Price, DavidUniversity of Aberdeen,Observational and Pragmatic Research Institute Pte Ltd
(author)
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Bateman, Eric D.University of Cape Town
(author)
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Bjermer, LeifUniversity of Groningen(Swepub:lu)lung-lbj
(author)
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Van Boven, Job F.M.University Medical Center Groningen
(author)
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Brusselle, GuyGhent University Hospital
(author)
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Costello, Richard W.Royal College of Surgeons in Ireland
(author)
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Dandurand, Ronald J.McGill University Health Center
(author)
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Diamant, ZuzanaLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University Medical Center Groningen(Swepub:lu)med-zdt
(author)
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Van Ganse, EricClaude Bernard University Lyon 1
(author)
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Gouder, CarolineMater Dei Hospital
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Van Kampen, Sanne C.Respiratory Effectiveness Group
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Kaplan, AlanUniversity of Toronto
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Kocks, JanwillemObservational and Pragmatic Research Institute Pte Ltd
(author)
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Miravitlles, MarcVall d'Hebron University Hospital
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Niimi, AkioNagoya City University
(author)
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Pizzichini, EmilioFederal University of Santa Catarina
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Rhee, Chin KookCatholic University of Korea
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Soriano, Joan B.Hospital Universitario de la Princesa
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Vogelmeier, ClausPhilipp University of Marburg
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Roman-Rodriguez, Miguel
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Carter, VictoriaObservational and Pragmatic Research Institute Pte Ltd,Optimum Patient Care Ltd
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D'Urzo, Anthony D.University of Toronto
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Roche, NicolasParis Descartes University
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University of Illinois at ChicagoUniversity of Oxford
(creator_code:org_t)
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In:Annals of the American Thoracic Society16:9, s. 1143-11502325-6621
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Krishnan, Jerry ...
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Nibber, Anjan
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Chisholm, Alison
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Price, David
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Bateman, Eric D.
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Bjermer, Leif
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Van Boven, Job F ...
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Brusselle, Guy
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Costello, Richar ...
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Diamant, Zuzana
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Van Ganse, Eric
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Gouder, Caroline
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Van Kampen, Sann ...
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Kaplan, Alan
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Kocks, Janwillem
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Miravitlles, Mar ...
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Niimi, Akio
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Pizzichini, Emil ...
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Rhee, Chin Kook
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Soriano, Joan B.
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Vogelmeier, Clau ...
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Roche, Nicolas
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