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Low-grade inflammat...
Low-grade inflammation in persons with recently diagnosed type 2 diabetes : The role of abdominal adiposity and putative mediators
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- Domazet, Sidsel L. (author)
- Odense University Hospital,University of Southern Denmark,Aarhus University Hospital
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- Olesen, Thomas B. (author)
- Odense University Hospital
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- Stidsen, Jacob V. (author)
- Odense University Hospital
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- Svensson, Camilla K. (author)
- Aarhus University Hospital,Holbæk Hospital
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- Nielsen, Jens S. (author)
- University of Southern Denmark,Odense University Hospital
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- Thomsen, Reimar W. (author)
- Aarhus University Hospital
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- Jessen, Niels (author)
- Aarhus University Hospital
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- Vestergaard, Peter (author)
- Aalborg University Hospital
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- Andersen, Mette K. (author)
- Novo Nordisk Foundation Centre for Basic Metabolic Research
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- Hansen, Torben (author)
- Novo Nordisk Foundation Centre for Basic Metabolic Research
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- Brøns, Charlotte (author)
- Steno Diabetes Center Copenhagen
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- Jensen, Verena H. (author)
- Steno Diabetes Center Copenhagen
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- Vaag, Allan A. (author)
- Lund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Steno Diabetes Center Copenhagen
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- Olsen, Michael H. (author)
- Holbæk Hospital
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- Højlund, Kurt (author)
- Odense University Hospital,University of Southern Denmark
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(creator_code:org_t)
- English.
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In: Diabetes, Obesity and Metabolism. - 1462-8902.
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Abstract
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- Aims: To determine the magnitude of the association between abdominal adiposity and low-grade inflammation in persons with recently diagnosed type 2 diabetes (T2D) and to determine to what extent this association is mediated by low physical activity level, hyperinsulinaemia, hyperglycaemia, dyslipidaemia, hypertension, and comorbidities. Materials and Methods: We measured waist circumference, clinical characteristics, and inflammatory markers i.e. tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hsCRP), in >9000 persons with recently diagnosed T2D. We applied multiple mediation analysis using structural equation modelling, with adjustment for age and sex. Results: Waist circumference as a proxy for abdominal adiposity was positively associated with all inflammatory markers. Hence, a one-standard deviation (SD) increase in waist circumference (SD = 15 cm) was associated with a 22%, 35%, and 46% SD increase in TNF-α (SD = 1.5 pg/mL), IL-6 (SD = 4.4 pg/mL), and hsCRP (SD = 6.9 mg/L), respectively. The level of hyperinsulinaemia assessed by fasting C-peptide was quantitatively the most important mediator, accounting for 9%–25% of the association between abdominal adiposity and low-grade inflammation, followed by low physical activity (5%–7%) and high triglyceride levels (2%–6%). Although mediation of adiposity-induced inflammation by greater comorbidity and higher glycated haemoglobin levels reached statistical significance, their impact was minor (1%–2%). Conclusions: In persons with recently diagnosed T2D, there was a clear association between abdominal adiposity and low-grade inflammation. A considerable part (20%–40%) of this association was mediated by other factors, with hyperinsulinaemia as a potentially important driver of adiposity-induced inflammation in T2D.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- body composition
- cohort study
- insulin resistance
- observational study
- population study
- type 2 diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Domazet, Sidsel ...
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Olesen, Thomas B ...
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Stidsen, Jacob V ...
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Svensson, Camill ...
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Nielsen, Jens S.
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Thomsen, Reimar ...
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show more...
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Jessen, Niels
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Vestergaard, Pet ...
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Andersen, Mette ...
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Hansen, Torben
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Brøns, Charlotte
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Jensen, Verena H ...
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Vaag, Allan A.
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Olsen, Michael H ...
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Højlund, Kurt
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Diabetes, Obesit ...
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Lund University