Low-grade inflammation in persons with recently diagnosed type 2 diabetes : The role of abdominal adiposity and putative mediators

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:lup.lub.lu.se:09721a5b-4277-4d7e-a9d3-af1f3c732e09" > Low-grade inflammat...

1 of 1
Previous record
Next record
To hitlist

Low-grade inflammation in persons with recently diagnosed type 2 diabetes : The role of abdominal adiposity and putative mediators

Domazet, Sidsel L. (author): University of Southern Denmark,Odense University Hospital,Aarhus University Hospital

Olesen, Thomas B. (author): Odense University Hospital

Stidsen, Jacob V. (author): Odense University Hospital

Svensson, Camilla K. (author): Aarhus University Hospital,Holbæk Hospital

Nielsen, Jens S. (author): Odense University Hospital,University of Southern Denmark

Thomsen, Reimar W. (author): Aarhus University Hospital

Jessen, Niels (author): Aarhus University Hospital

Vestergaard, Peter (author): Aalborg University Hospital

Andersen, Mette K. (author): Novo Nordisk Foundation Centre for Basic Metabolic Research

Hansen, Torben (author): Novo Nordisk Foundation Centre for Basic Metabolic Research

Brøns, Charlotte (author): Steno Diabetes Center Copenhagen

Jensen, Verena H. (author): Steno Diabetes Center Copenhagen

Vaag, Allan A. (author): Lund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Steno Diabetes Center Copenhagen

Olsen, Michael H. (author): Holbæk Hospital

Højlund, Kurt (author): University of Southern Denmark,Odense University Hospital

show less...

(creator_code:org_t)


English.
In: Diabetes, Obesity and Metabolism. - 1462-8902.

Related links:: http://dx.doi.org/10... (free); show more...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Aims: To determine the magnitude of the association between abdominal adiposity and low-grade inflammation in persons with recently diagnosed type 2 diabetes (T2D) and to determine to what extent this association is mediated by low physical activity level, hyperinsulinaemia, hyperglycaemia, dyslipidaemia, hypertension, and comorbidities. Materials and Methods: We measured waist circumference, clinical characteristics, and inflammatory markers i.e. tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hsCRP), in >9000 persons with recently diagnosed T2D. We applied multiple mediation analysis using structural equation modelling, with adjustment for age and sex. Results: Waist circumference as a proxy for abdominal adiposity was positively associated with all inflammatory markers. Hence, a one-standard deviation (SD) increase in waist circumference (SD = 15 cm) was associated with a 22%, 35%, and 46% SD increase in TNF-α (SD = 1.5 pg/mL), IL-6 (SD = 4.4 pg/mL), and hsCRP (SD = 6.9 mg/L), respectively. The level of hyperinsulinaemia assessed by fasting C-peptide was quantitatively the most important mediator, accounting for 9%–25% of the association between abdominal adiposity and low-grade inflammation, followed by low physical activity (5%–7%) and high triglyceride levels (2%–6%). Although mediation of adiposity-induced inflammation by greater comorbidity and higher glycated haemoglobin levels reached statistical significance, their impact was minor (1%–2%). Conclusions: In persons with recently diagnosed T2D, there was a clear association between abdominal adiposity and low-grade inflammation. A considerable part (20%–40%) of this association was mediated by other factors, with hyperinsulinaemia as a potentially important driver of adiposity-induced inflammation in T2D.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

body composition
cohort study
insulin resistance
observational study
population study
type 2 diabetes

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

Diabetes, Obesity and Metabolism (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Domazet, Sidsel ...; Olesen, Thomas B ...; Stidsen, Jacob V ...; Svensson, Camill ...; Nielsen, Jens S.; Thomsen, Reimar ...; show more...; Jessen, Niels; Vestergaard, Pet ...; Andersen, Mette ...; Hansen, Torben; Brøns, Charlotte; Jensen, Verena H ...; Vaag, Allan A.; Olsen, Michael H ...; Højlund, Kurt; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: Diabetes, Obesit ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se