SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:09721a5b-4277-4d7e-a9d3-af1f3c732e09"
 

Search: onr:"swepub:oai:lup.lub.lu.se:09721a5b-4277-4d7e-a9d3-af1f3c732e09" > Low-grade inflammat...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Domazet, Sidsel L.University of Southern Denmark,Odense University Hospital,Aarhus University Hospital (author)

Low-grade inflammation in persons with recently diagnosed type 2 diabetes : The role of abdominal adiposity and putative mediators

  • Article/chapterEnglish

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:09721a5b-4277-4d7e-a9d3-af1f3c732e09
  • https://lup.lub.lu.se/record/09721a5b-4277-4d7e-a9d3-af1f3c732e09URI
  • https://doi.org/10.1111/dom.15514DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aims: To determine the magnitude of the association between abdominal adiposity and low-grade inflammation in persons with recently diagnosed type 2 diabetes (T2D) and to determine to what extent this association is mediated by low physical activity level, hyperinsulinaemia, hyperglycaemia, dyslipidaemia, hypertension, and comorbidities. Materials and Methods: We measured waist circumference, clinical characteristics, and inflammatory markers i.e. tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hsCRP), in >9000 persons with recently diagnosed T2D. We applied multiple mediation analysis using structural equation modelling, with adjustment for age and sex. Results: Waist circumference as a proxy for abdominal adiposity was positively associated with all inflammatory markers. Hence, a one-standard deviation (SD) increase in waist circumference (SD = 15 cm) was associated with a 22%, 35%, and 46% SD increase in TNF-α (SD = 1.5 pg/mL), IL-6 (SD = 4.4 pg/mL), and hsCRP (SD = 6.9 mg/L), respectively. The level of hyperinsulinaemia assessed by fasting C-peptide was quantitatively the most important mediator, accounting for 9%–25% of the association between abdominal adiposity and low-grade inflammation, followed by low physical activity (5%–7%) and high triglyceride levels (2%–6%). Although mediation of adiposity-induced inflammation by greater comorbidity and higher glycated haemoglobin levels reached statistical significance, their impact was minor (1%–2%). Conclusions: In persons with recently diagnosed T2D, there was a clear association between abdominal adiposity and low-grade inflammation. A considerable part (20%–40%) of this association was mediated by other factors, with hyperinsulinaemia as a potentially important driver of adiposity-induced inflammation in T2D.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Olesen, Thomas B.Odense University Hospital (author)
  • Stidsen, Jacob V.Odense University Hospital (author)
  • Svensson, Camilla K.Aarhus University Hospital,Holbæk Hospital (author)
  • Nielsen, Jens S.Odense University Hospital,University of Southern Denmark (author)
  • Thomsen, Reimar W.Aarhus University Hospital (author)
  • Jessen, NielsAarhus University Hospital (author)
  • Vestergaard, PeterAalborg University Hospital (author)
  • Andersen, Mette K.Novo Nordisk Foundation Centre for Basic Metabolic Research (author)
  • Hansen, TorbenNovo Nordisk Foundation Centre for Basic Metabolic Research (author)
  • Brøns, CharlotteSteno Diabetes Center Copenhagen(Swepub:lu)ch8338br (author)
  • Jensen, Verena H.Steno Diabetes Center Copenhagen (author)
  • Vaag, Allan A.Lund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Steno Diabetes Center Copenhagen(Swepub:lu)med-ava (author)
  • Olsen, Michael H.Holbæk Hospital (author)
  • Højlund, KurtUniversity of Southern Denmark,Odense University Hospital (author)
  • University of Southern DenmarkOdense University Hospital (creator_code:org_t)

Related titles

  • In:Diabetes, Obesity and Metabolism1462-8902

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view