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Low-grade inflammat...
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Domazet, Sidsel L.University of Southern Denmark,Odense University Hospital,Aarhus University Hospital
(author)
Low-grade inflammation in persons with recently diagnosed type 2 diabetes : The role of abdominal adiposity and putative mediators
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LIBRIS-ID:oai:lup.lub.lu.se:09721a5b-4277-4d7e-a9d3-af1f3c732e09
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https://lup.lub.lu.se/record/09721a5b-4277-4d7e-a9d3-af1f3c732e09URI
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https://doi.org/10.1111/dom.15514DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Aims: To determine the magnitude of the association between abdominal adiposity and low-grade inflammation in persons with recently diagnosed type 2 diabetes (T2D) and to determine to what extent this association is mediated by low physical activity level, hyperinsulinaemia, hyperglycaemia, dyslipidaemia, hypertension, and comorbidities. Materials and Methods: We measured waist circumference, clinical characteristics, and inflammatory markers i.e. tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hsCRP), in >9000 persons with recently diagnosed T2D. We applied multiple mediation analysis using structural equation modelling, with adjustment for age and sex. Results: Waist circumference as a proxy for abdominal adiposity was positively associated with all inflammatory markers. Hence, a one-standard deviation (SD) increase in waist circumference (SD = 15 cm) was associated with a 22%, 35%, and 46% SD increase in TNF-α (SD = 1.5 pg/mL), IL-6 (SD = 4.4 pg/mL), and hsCRP (SD = 6.9 mg/L), respectively. The level of hyperinsulinaemia assessed by fasting C-peptide was quantitatively the most important mediator, accounting for 9%–25% of the association between abdominal adiposity and low-grade inflammation, followed by low physical activity (5%–7%) and high triglyceride levels (2%–6%). Although mediation of adiposity-induced inflammation by greater comorbidity and higher glycated haemoglobin levels reached statistical significance, their impact was minor (1%–2%). Conclusions: In persons with recently diagnosed T2D, there was a clear association between abdominal adiposity and low-grade inflammation. A considerable part (20%–40%) of this association was mediated by other factors, with hyperinsulinaemia as a potentially important driver of adiposity-induced inflammation in T2D.
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Olesen, Thomas B.Odense University Hospital
(author)
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Stidsen, Jacob V.Odense University Hospital
(author)
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Svensson, Camilla K.Aarhus University Hospital,Holbæk Hospital
(author)
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Nielsen, Jens S.Odense University Hospital,University of Southern Denmark
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Thomsen, Reimar W.Aarhus University Hospital
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Jessen, NielsAarhus University Hospital
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Vestergaard, PeterAalborg University Hospital
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Andersen, Mette K.Novo Nordisk Foundation Centre for Basic Metabolic Research
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Hansen, TorbenNovo Nordisk Foundation Centre for Basic Metabolic Research
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Brøns, CharlotteSteno Diabetes Center Copenhagen(Swepub:lu)ch8338br
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Jensen, Verena H.Steno Diabetes Center Copenhagen
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Vaag, Allan A.Lund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Steno Diabetes Center Copenhagen(Swepub:lu)med-ava
(author)
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Olsen, Michael H.Holbæk Hospital
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Højlund, KurtUniversity of Southern Denmark,Odense University Hospital
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University of Southern DenmarkOdense University Hospital
(creator_code:org_t)
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In:Diabetes, Obesity and Metabolism1462-8902
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Domazet, Sidsel ...
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Olesen, Thomas B ...
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Stidsen, Jacob V ...
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Svensson, Camill ...
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Nielsen, Jens S.
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Thomsen, Reimar ...
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Jessen, Niels
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Vestergaard, Pet ...
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Andersen, Mette ...
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Hansen, Torben
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Brøns, Charlotte
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Jensen, Verena H ...
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Vaag, Allan A.
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Olsen, Michael H ...
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Højlund, Kurt
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