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Marginal-Zone B-Cel...
Marginal-Zone B-Cells are main producers of IgM in humans, and are reduced in patients with autoimmune vasculitis
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- Appelgren, Daniel (author)
- Linköpings universitet,Linköping University,Avdelningen för läkemedelsforskning,Medicinska fakulteten
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- Eriksson, Per (author)
- Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Ernerudh, Jan (author)
- Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin
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- Segelmark, Mårten (author)
- Linköpings universitet,Linköping University,Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Avdelningen för läkemedelsforskning,Region Östergötland, Njurmedicinska kliniken US,Lund Univ, Sweden; Skane Univ Hosp, Sweden
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(creator_code:org_t)
- 2018-10-02
- 2018
- English.
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In: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 9:OCT
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Abstract
Subject headings
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- In mice, B1 and marginal zone (MZ) B-cells play an important role in prevention of autoimmunity through production of regulatory cytokines and natural antibodies. There is limited knowledge about the human counterparts of these cells. We therefore investigated functions of MZ-like B-cells and the frequency of circulating MZ-like and B1-like B-cells in healthy controls (HC), as well as in patients with autoimmune vasculitis to learn more about the role of these cells in autoimmune disease. After stimulation with CpG oligodeoxynucleotides (ODN) of class B in vitro, MZ-like B-cells were the main producers of IgM whereas switched memory B-cells primarily produced IgG and IgA. TNF and IL-10 were produced by both MZ-like and switched memory B-cells. Neither antibody nor TNF/IL-10 production by the B-cell subsets differed between patients and HC. Patients with autoimmune vasculitis, irrespective of disease activity, had lower percentage and absolute numbers of circulating MZ-like B-cells, and lower absolute numbers of B1-like B-cells. The percentage of B1-like B-cells was reduced during active disease. These findings remained significant when the analysis was confined to active treatment-naïve patients (disease onset). Our results suggest that human innate-like B-cells might have a physiological role in prevention of autoimmunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- Anti-neutrophil cytoplasmic autantibody (ANCA) associated vasculitis
- Autoimmunity
- B1 B-cells
- IgM
- Innate-like B-cells
- Marginal-zone (MZ) B-cells
- Natural antibodies
- T-cell-independent antibodies
- marginal-zone (MZ) B-cells; B1 B-cells; innate-like B-cells; natural antibodies; T-cell-independent antibodies; IgM; autoimmunity; anti-neutrophil cytoplasmic autantibody (ANCA) associated vasculitis
Publication and Content Type
- art (subject category)
- ref (subject category)
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