Search: onr:"swepub:oai:lup.lub.lu.se:0b1e5557-2a55-4e50-bf36-2e389ea8abd2" > Studies on the Prot...
Fältnamn | Indikatorer | Metadata |
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000 | 03347naa a2200385 4500 | |
001 | oai:lup.lub.lu.se:0b1e5557-2a55-4e50-bf36-2e389ea8abd2 | |
003 | SwePub | |
008 | 180205s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/0b1e5557-2a55-4e50-bf36-2e389ea8abd22 URI |
024 | 7 | a https://doi.org/10.1038/s41598-018-20041-92 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Adav, Sunil S.u Nanyang Technological University4 aut |
245 | 1 0 | a Studies on the Proteome of Human Hair - Identification of Histones and Deamidated Keratins |
264 | c 2018-01-25 | |
264 | 1 | b Springer Science and Business Media LLC,c 2018 |
520 | a Human hair is laminar-fibrous tissue and an evolutionarily old keratinization product of follicle trichocytes. Studies on the hair proteome can give new insights into hair function and lead to the development of novel biomarkers for hair in health and disease. Human hair proteins were extracted by detergent and detergent-free techniques. We adopted a shotgun proteomics approach, which demonstrated a large extractability and variety of hair proteins after detergent extraction. We found an enrichment of keratin, keratin-associated proteins (KAPs), and intermediate filament proteins, which were part of protein networks associated with response to stress, innate immunity, epidermis development, and the hair cycle. Our analysis also revealed a significant deamidation of keratin type I and II, and KAPs. The hair shafts were found to contain several types of histones, which are well known to exert antimicrobial activity. Analysis of the hair proteome, particularly its composition, protein abundances, deamidated hair proteins, and modification sites, may offer a novel approach to explore potential biomarkers of hair health quality, hair diseases, and aging. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
700 | 1 | a Subbaiaih, Roopa S.u Nanyang Technological University4 aut |
700 | 1 | a Kerk, Swat Kimu Nanyang Technological University4 aut |
700 | 1 | a Lee, Amelia Yilinu Nanyang Technological University4 aut |
700 | 1 | a Lai, Hui Yingu Nanyang Technological University4 aut |
700 | 1 | a Ng, Kee Woeiu Nanyang Technological University,Skin Research Institute of Singapore4 aut |
700 | 1 | a Sze, Siu Kwanu Nanyang Technological University4 aut |
700 | 1 | a Schmidtchen, Arturu Lund University,Lunds universitet,Schmidtchen lab,Forskargrupper vid Lunds universitet,Schmidtchen Lab,Lund University Research Groups,Nanyang Technological University,University of Copenhagen4 aut0 (Swepub:lu)derm-asc |
710 | 2 | a Nanyang Technological Universityb Skin Research Institute of Singapore4 org |
773 | 0 | t Scientific Reportsd : Springer Science and Business Media LLCg 8:1q 8:1x 2045-2322 |
856 | 4 | u http://dx.doi.org/10.1038/s41598-018-20041-9x freey FULLTEXT |
856 | 4 | u https://www.nature.com/articles/s41598-018-20041-9.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/0b1e5557-2a55-4e50-bf36-2e389ea8abd2 |
856 | 4 8 | u https://doi.org/10.1038/s41598-018-20041-9 |
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