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Breast cancer survi...
Breast cancer survival in Nordic BRCA2 mutation carriers—unconventional association with oestrogen receptor status
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- Olafsdottir, Elinborg J. (author)
- Icelandic Cancer Registry
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- Borg, Ake (author)
- Lund University,Lunds universitet,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Jensen, Maj Britt (author)
- Copenhagen University Hospital
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- Gerdes, Anne Marie (author)
- Copenhagen University Hospital
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- Johansson, Anna L.V. (author)
- Karolinska Institutet,Karolinska Institute
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- Barkardottir, Rosa B (author)
- University of Iceland,National University Hospital of Iceland
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- Johannsson, Oskar T. (author)
- National University Hospital of Iceland
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- Ejlertsen, Bent (author)
- Copenhagen University Hospital
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- Sønderstrup, Ida Marie Heeholm (author)
- Zealand University Hospital
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- Hovig, Eivind (author)
- Oslo university hospital
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- Lænkholm, Anne Vibeke (author)
- Slagelse Hospital
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- Hansen, Thomas van Overeem (author)
- Copenhagen University Hospital
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- Olafsdottir, Gudridur H. (author)
- Icelandic Cancer Registry
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- Rossing, Maria (author)
- Copenhagen University Hospital
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- Jonasson, Jon G. (author)
- National University Hospital of Iceland,University of Iceland
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- Sigurdsson, Stefan (author)
- University of Iceland
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- Loman, Niklas (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Nilsson, Martin P. (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Narod, Steven A. (author)
- University of Toronto
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- Tryggvadottir, Laufey (author)
- Icelandic Cancer Registry,University of Iceland
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(creator_code:org_t)
- 2020-09-17
- 2020
- English 8 s.
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 123:11, s. 1608-1615
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Abstract
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- Background: The natural history of breast cancer among BRCA2 carriers has not been clearly established. In a previous study from Iceland, positive ER status was a negative prognostic factor. We sought to identify factors that predicted survival after invasive breast cancer in an expanded cohort of BRCA2 carriers. Methods: We studied 608 women with invasive breast cancer and a pathogenic BRCA2 mutation (variant) from four Nordic countries. Information on prognostic factors and treatment was retrieved from health records and by analysis of archived tissue specimens. Hazard ratios (HR) were estimated for breast cancer-specific survival using Cox regression. Results: About 77% of cancers were ER-positive, with the highest proportion (83%) in patients under 40 years. ER-positive breast cancers were more likely to be node-positive (59%) than ER-negative cancers (34%) (P < 0.001). The survival analysis included 584 patients. Positive ER status was protective in the first 5 years from diagnosis (multivariate HR = 0.49; 95% CI 0.26–0.93, P = 0.03); thereafter, the effect was adverse (HR = 1.91; 95% CI 1.07–3.39, P = 0.03). The adverse effect of positive ER status was limited to women who did not undergo endocrine treatment (HR = 2.36; 95% CI 1.26–4.44, P = 0.01) and patients with intact ovaries (HR = 1.99; 95% CI 1.11–3.59, P = 0.02). Conclusions: The adverse effect of a positive ER status in BRCA2 carriers with breast cancer may be contingent on exposure to ovarian hormones.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- art (subject category)
- ref (subject category)
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Olafsdottir, Eli ...
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Borg, Ake
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Jensen, Maj Brit ...
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Gerdes, Anne Mar ...
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Johansson, Anna ...
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Barkardottir, Ro ...
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Johannsson, Oska ...
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Ejlertsen, Bent
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Sønderstrup, Ida ...
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Hovig, Eivind
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Lænkholm, Anne V ...
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Hansen, Thomas v ...
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Olafsdottir, Gud ...
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Rossing, Maria
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Jonasson, Jon G.
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Sigurdsson, Stef ...
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Loman, Niklas
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Nilsson, Martin ...
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Narod, Steven A.
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Tryggvadottir, L ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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MEDICAL AND HEAL ...
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and Health Sciences
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Lund University
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Karolinska Institutet