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UPF2 Is a Critical ...
UPF2 Is a Critical Regulator of Liver Development, Function and Regeneration
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-07-19
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Public Library of Science (PLoS),2010
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:0b7a2c78-15d9-4f2a-842d-14a71d1f4691
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https://lup.lub.lu.se/record/1654809URI
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https://doi.org/10.1371/journal.pone.0011650DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: Nonsense-mediated mRNA decay (NMD) is a post-transcriptional RNA surveillance process that facilitates the recognition and destruction of mRNAs bearing premature terminations codons (PTCs). Such PTC-containing (PTC+) mRNAs may arise from different processes, including erroneous processing and expression of pseudogenes, but also from more regulated events such as alternative splicing coupled NMD (AS-NMD). Thus, the NMD pathway serves both as a silencer of genomic noise and a regulator of gene expression. Given the early embryonic lethality in NMD deficient mice, uncovering the full regulatory potential of the NMD pathway in mammals will require the functional assessment of NMD in different tissues. Methodology/Principal Findings: Here we use mouse genetics to address the role of UPF2, a core NMD component, in the development, function and regeneration of the liver. We find that loss of NMD during fetal liver development is incompatible with postnatal life due to failure of terminal differentiation. Moreover, deletion of Upf2 in the adult liver results in hepatosteatosis and disruption of liver homeostasis. Finally, NMD was found to be absolutely required for liver regeneration. Conclusion/Significance: Collectively, our data demonstrate the critical role of the NMD pathway in liver development, function and regeneration and highlights the importance of NMD for mammalian biology.
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Norgaard, Gitte A.
(author)
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Weischenfeldt, Joachim
(author)
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Waage, Johannes
(author)
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Jakobsen, Janus S.
(author)
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Damgaard, Inge
(author)
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Mohlin, FridaLund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups(Swepub:lu)med-fbr
(author)
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Blom, AnnaLund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-abl
(author)
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Borup, Rehannah
(author)
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Bisgaard, Hanne Cathrine
(author)
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Porse, Bo T.
(author)
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Proteinkemi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:PLoS ONE: Public Library of Science (PLoS)5:71932-6203
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Thoren, Lina A.
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Norgaard, Gitte ...
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Weischenfeldt, J ...
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Waage, Johannes
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Jakobsen, Janus ...
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Damgaard, Inge
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Mohlin, Frida
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Blom, Anna
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Borup, Rehannah
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Bisgaard, Hanne ...
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Porse, Bo T.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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PLoS ONE
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Lund University