Integration of acousto- and dielectrophoresis allows tumor cell separation and enrichment followed by arraying of target cells toward analysis of circulating tumor cells at the single-cell level

• We present an advanced approach for single-cell analysis of circulating tumor cells (CTCs) by integrating an acoustofluidic chip for sample preparation, including simultaneous acoustophoretic separation and enrichment of the separated cells, onto an electroactive microwell array (EMA) for single-cell arraying. The integrated device shows highly efficient cell recovery of target cells (82.5%) and depletion of non-target cells (92.8%).

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)

Keyword

Acoustophoresis

Circulating tumor cells

Dielectrophoresis

Publication and Content Type

kon (subject category)

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