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Mapping the cord bl...
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Hatem, GadLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
(author)
Mapping the cord blood transcriptome of pregnancies affected by early maternal anemia to identify signatures of fetal programming
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-01-11
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The Endocrine Society,2022
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LIBRIS-ID:oai:lup.lub.lu.se:0c545649-8190-425b-a760-b19bf59007f9
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https://lup.lub.lu.se/record/0c545649-8190-425b-a760-b19bf59007f9URI
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https://doi.org/10.1210/clinem/dgac010DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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OBJECTIVE: Anemia during early pregnancy (EP) is common in developing countries and is associated with adverse health consequences for both mother and children. Offspring of women with EP anemia often have low birth-weight, the latter being a risk factor for cardiometabolic diseases including type 2 diabetes (T2D) later in life. Mechanisms underlying developmental programming of adult cardiometabolic disease include epigenetic and transcriptional alterations potentially detectable in umbilical cord blood (UCB) at time of birth.METHODS: We leveraged global transcriptome- and accompanying epigenome-wide changes in 48 UCB from newborns of EP-anemic Tanzanian mothers and 50 controls to identify differentially expressed genes (DEG) in UCB exposed to maternal EP-anemia. DEGs were assessed for association with neonatal anthropometry and cord insulin levels. These genes were further studied in expression data from human fetal pancreas and adult islets to understand their role in beta-cell development and/or function.RESULTS: The expression of 137 genes was altered in UCB of newborns exposed to maternal EP anemia. These putative signatures of fetal programming which included the birth-weight locus LCORL, were potentially mediated by epigenetic changes in 27 genes and associated with neonatal anthropometry. Among the DEGs were P2RX7, PIK3C2B, and NUMBL which potentially influence beta-cell development. Insulin levels were lower in EP anemia exposed UCB, supporting the notion of developmental programming of pancreatic beta-cell dysfunction and subsequently increased risk of T2D in offspring of EP anemic mothers.CONCLUSIONS: Our data provide proof-of-concept on distinct transcriptional and epigenetic changes detectable in UCB from newborns exposed to maternal EP anemia.
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Hjort, LineCopenhagen University Hospital(Swepub:lu)li1517hj
(author)
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Asplund, OlofLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)med-oap
(author)
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Minja, Daniel T RNational Institute for Medical Research Tanga
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Msemo, Omari AbdulNational Institute for Medical Research Tanga
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Møller, Sofie LykkeUniversity of Copenhagen
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Lavstsen, ThomasUniversity of Copenhagen
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Groth-Grunnet, LouiseUniversity of Copenhagen
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Lusingu, John P ANational Institute for Medical Research Tanga
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Hansson, OlaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)medk-oha
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Christensen, Dirk LundUniversity of Copenhagen
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Vaag, Allan ASteno Diabetes Center Copenhagen(Swepub:lu)med-ava
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Artner, IsabellaLund University,Lunds universitet,Endokrin Celldifferentiering,Forskargrupper vid Lunds universitet,Endocrine Cell Differentiation and Function,Lund University Research Groups(Swepub:lu)med-iba
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Theander, ThorUniversity of Copenhagen
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Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)endo-lgr
(author)
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Schmiegelow, ChristentzeUniversity of Copenhagen
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Bygbjerg, Ib ChristianUniversity of Copenhagen
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Prasad, Rashmi BLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)med-rpa
(author)
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Translationell muskelforskningForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:The Journal of clinical endocrinology and metabolism: The Endocrine Society107:5, s. 1303-13161945-71970021-972X
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Hatem, Gad
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Hjort, Line
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Asplund, Olof
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Minja, Daniel T ...
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Lavstsen, Thomas
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Vaag, Allan A
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Artner, Isabella
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Groop, Leif
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Prasad, Rashmi B
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