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  • Bjelosevic, HarisLund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH (author)

Platinum(II) and gold(I) complexes based on 1,1 '-bis(diphenylphosphino)metallocene derivatives: Synthesis, characterization and biological activity of the gold complexes

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • Elsevier BV,2012

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  • LIBRIS-ID:oai:lup.lub.lu.se:0cabb818-3ad4-44a0-b785-e421a8bce404
  • https://lup.lub.lu.se/record/3256255URI
  • https://doi.org/10.1016/j.jorganchem.2012.08.034DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The synthesis of series of 1,2,1' substituted bis(diphenylphosphino)- ruthenocenyl (1-4) and ferrocenyl cis-platinum(II) (5-7) and gold(I) (8-12) complexes are described. Crystal structures of 2 and 4, as well as 5, 6 and 10 confirm the molecular geometry of these ligands and their metal complexes. Preliminary investigation of four gold complexes as potential anticancer, antiHIV and antimalaria showed at least one gold compound that has excellent activity towards one of these diseases. The three gold(I) complexes, {1- [1-(dimethylamino)ethyl]-1 ,2-bis(diphenylphosphino)ruthenocene-kappa P-2,P'}bis[chlorogold(I)] (8) (IC50 = 1.40 mu M), {1-[1-(acetoxyethyl)-1',2-bis(diphenylphosphino)ferrocene-kappa P-2,P']bis[chlorogold(1)] (9) (IC50 = 0.51 mu M), {1-[1-(3-carboxypropanamido)ethyl]-1',2-bis(diphenylphosphino)-ruthenocene kappa P-2,P'} bis[chlorogold(I)] (12) (IC50 = 1.784 mu M), have the best activities against cancer, HIV and malaria respectively. (C) 2012 Elsevier B.V. All rights reserved.

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  • Guzei, Ilia A. (author)
  • Spencer, Lara C. (author)
  • Persson, TinaLund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)orgk-tpe (author)
  • Kriel, Frederik H. (author)
  • Hewer, Raymond (author)
  • Nell, Margo J. (author)
  • Gut, Jiri (author)
  • van Rensburg, Constance E. J. (author)
  • Rosenthal, Philip J. (author)
  • Coates, Judy (author)
  • Darkwa, James (author)
  • Elmroth, SofiLund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ook1-sel (author)
  • Centrum för analys och syntesKemiska institutionen (creator_code:org_t)

Related titles

  • In:Journal of Organometallic Chemistry: Elsevier BV720, s. 52-590022-328X

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