Age- and gender-specific upper limits and reference equations for workload-indexed systolic blood pressure response during bicycle ergometry

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Hedman, Kristofer,1984-Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US (author)

Age- and gender-specific upper limits and reference equations for workload-indexed systolic blood pressure response during bicycle ergometry

Article/chapterEnglish2021

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2020-03-10
Oxford University Press (OUP),2021

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LIBRIS-ID:oai:lup.lub.lu.se:0cd1984c-2161-4b11-85e1-e51766ccc245
https://lup.lub.lu.se/record/0cd1984c-2161-4b11-85e1-e51766ccc245URI
https://doi.org/10.1177/2047487320909667DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-165242URI

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Language:English
Summary in:English

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Funding Agencies|County Council of Ostergotland, Sweden [LIO822461]; Scientific Committee of Blekinge County Council, Sweden
Background: Guidelines recommend considering workload in interpretation of the systolic blood pressure (SBP) response to exercise, but reference values are lacking. Design: This was a retrospective, consecutive cohort study. Methods: From 12,976 subjects aged 18–85 years who performed a bicycle ergometer exercise test at one centre in Sweden during the years 2005–2016, we excluded those with prevalent cardiovascular disease, comorbidities, cardiac risk factors or medications. We extracted SBP, heart rate and workload (watt) from ≥ 3 time points from each test. The SBP/watt-slope and the SBP/watt-ratio at peak exercise were calculated. Age- and sex-specific mean values, standard deviations and 90th and 95th percentiles were determined. Reference equations for workload-indexed and peak SBP were derived using multiple linear regression analysis, including sex, age, workload, SBP at rest and anthropometric variables as predictors. Results: A final sample of 3839 healthy subjects (n = 1620 female) were included. While females had lower mean peak SBP than males (188 ± 24 vs 202 ± 22 mmHg, p < 0.001), workload-indexed SBP measures were markedly higher in females; SBP/watt-slope: 0.52 ± 0.21 versus 0.41 ± 0.15 mmHg/watt (p < 0.001); peak SBP/watt-ratio: 1.35 ± 0.34 versus 0.90 ± 0.21 mmHg/watt (p < 0.001). Age, sex, exercise capacity, resting SBP and height were significant predictors of the workload-indexed SBP parameters and were included in the reference equations. Conclusions: These novel reference values can aid clinicians and exercise physiologists in interpreting the SBP response to exercise and may provide a basis for future research on the prognostic impact of exercise SBP. In females, a markedly higher SBP in relation to workload could imply a greater peripheral vascular resistance during exercise than in males.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Exercise testing
hypertension
reference values
Exercise testing; reference values; hypertension

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Lindow, ThomasLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Växjö Central Hospital,Vaxjo Cent Hosp, Sweden; Lund Univ, Sweden(Swepub:lu)th2511ak (author)
Elmberg, ViktorLund University,Lunds universitet,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Breathlessness and chronic respiratory failure,Lund University Research Groups,Blekinge Hospital,Lund Univ, Sweden; Blekinge Hosp, Sweden(Swepub:lu)vi1548el (author)
Brudin, Lars,1946-Kalmar County Hospital,Kalmar Cty Hosp, Sweden(Swepub:liu)larbr27 (author)
Ekström, MagnusLund University,Lunds universitet,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Breathlessness and chronic respiratory failure,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)med-mue (author)
Linköping UniversityAvdelningen för diagnostik och specialistmedicin (creator_code:org_t)

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In:European Journal of Preventive Cardiology: Oxford University Press (OUP)28:12, s. 1360-13692047-48732047-4881

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