Search: onr:"swepub:oai:lup.lub.lu.se:0cf4cddd-3300-4102-bdb0-ef459bc6c380" >
Implementing liquid...
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Quandt, DagmarMartin-Luther-Universität Halle-Wittenberg
(author)
Implementing liquid biopsies into clinical decision making for cancer immunotherapy
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-04-24
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Impact Journals, LLC,2017
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14 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:0cf4cddd-3300-4102-bdb0-ef459bc6c380
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https://lup.lub.lu.se/record/0cf4cddd-3300-4102-bdb0-ef459bc6c380URI
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https://doi.org/10.18632/oncotarget.17397DOI
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Language:English
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Summary in:English
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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During the last decade, novel immunotherapeutic strategies, in particular antibodies directed against immune checkpoint inhibitors, have revolutionized the treatment of different malignancies leading to an improved survival of patients. Identification of immune-related biomarkers for diagnosis, prognosis, monitoring of immune responses and selection of patients for specific cancer immunotherapies is urgently required and therefore areas of intensive research. Easily accessible samples in particular liquid biopsies (body fluids), such as blood, saliva or urine, are preferred for serial tumor biopsies. Although monitoring of immune and tumor responses prior, during and post immunotherapy has led to significant advances of patients' outcome, valid and stable prognostic biomarkers are still missing. This might be due to the limited capacity of the technologies employed, reproducibility of results as well as assay stability and validation of results. Therefore solid approaches to assess immune regulation and modulation as well as to follow up the nature of the tumor in liquid biopsies are urgently required to discover valuable and relevant biomarkers including sample preparation, timing of the collection and the type of liquid samples. This article summarizes our knowledge of the well-known liquid material in a new context as liquid biopsy and focuses on collection and assay requirements for the analysis and the technical developments that allow the implementation of different high-throughput assays to detect alterations at the genetic and immunologic level, which could be used for monitoring treatment efficiency, acquired therapy resistance mechanisms and the prognostic value of the liquid biopsies.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Zucht, Hans DieterProtagen Diagnostics
(author)
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Amann, ArnoMedical University of Innsbruck
(author)
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Wulf-Goldenberg, AnneEPO Berlin-Buch GmbH
(author)
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Borrebaeck, CarlLund University,Lunds universitet,Create Health,Annan verksamhet, LTH,Lunds Tekniska Högskola,Other operations, LTH,Faculty of Engineering, LTH(Swepub:lu)immt-cbo
(author)
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Cannarile, MichaelRoche Innovation Center
(author)
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Lambrechts, DietherFlanders Interuniversity Institute for Biotechnology
(author)
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Oberacher, HerbertMedical University of Innsbruck
(author)
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Garrett, JamesNovartis Institutes for BioMedical Research, Inc.
(author)
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Nayak, Tapan KumarRoche Innovation Center
(author)
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Kazinski, MichaelQiagen GmbH
(author)
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Massie, Charles
(author)
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Schwarzenbach, HeidiUniversity Medical Center Hamburg-Eppendorf
(author)
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Maio, Michele
(author)
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Prins, RobertJonsson Comprehensive Cancer Center
(author)
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Wendik, Björn
(author)
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Hockett, Richard
(author)
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Enderle, Daniel
(author)
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Noerholm, Mikkel
(author)
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Hendriks, Hans
(author)
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Zwierzina, HeinzMedical University of Innsbruck
(author)
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Seliger, BarbaraMartin-Luther-Universität Halle-Wittenberg
(author)
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Martin-Luther-Universität Halle-WittenbergProtagen Diagnostics
(creator_code:org_t)
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In:Oncotarget: Impact Journals, LLC8:29, s. 48507-485201949-2553
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Prins, Robert
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Wendik, Björn
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Hockett, Richard
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Hendriks, Hans
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Zwierzina, Heinz
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