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Hygiene may attenua...
Hygiene may attenuate selection for antibiotic resistance by changing microbial community structure
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- Aspenberg, Magnus (author)
- Lund University,Lunds universitet,Dynamiska system,Forskargrupper vid Lunds universitet,Dynamical systems,Lund University Research Groups
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- Maad Sasane, Sara (author)
- Lund University,Lunds universitet,Biomedical Modelling and Computation,Forskargrupper vid Lunds universitet,Partiella differentialekvationer,Matematik LTH,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,LTH profilområde: AI och digitalisering,LTH profilområden,Lund University Research Groups,Partial differential equations,Mathematics (Faculty of Engineering),Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: AI and Digitalization,LTH Profile areas,Faculty of Engineering, LTH
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- Nilsson, Fredrik (author)
- Skåne University Hospital
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- Brown, Sam P. (author)
- Georgia Institute of Technology
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- Wollein Waldetoft, Kristofer (author)
- Georgia Institute of Technology
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(creator_code:org_t)
- 2023-01-18
- 2023
- English.
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In: Evolution, Medicine and Public Health. - : Oxford University Press (OUP). - 2050-6201. ; 11:1
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Abstract
Subject headings
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- Good hygiene, in both health care and the community, is central to containing the rise of antibiotic resistance, as well as to infection control more generally. But despite the well-known importance, the ecological mechanisms by which hygiene (or other transmission control measures) affect the evolution of resistance remain to be elucidated. Using metacommunity ecology theory, we here propose that hygiene attenuates the effect of antibiotic selection pressure. Specifically, we predict that hygiene limits the scope for antibiotics to induce competitive release of resistant bacteria within treated hosts, and that this is due to an effect of hygiene on the distribution of resistant and sensitive strains in the host population. We show this in a mathematical model of bacterial metacommunity dynamics, and test the results against data on antibiotic resistance, antibiotic treatment, and the use of alcohol-based hand rub in long-term care facilities. The data are consistent with hand rub use attenuating the resistance promoting effect of antibiotic treatment. Our results underscore the importance of hygiene, and point to a concrete way to weaken the link between antibiotic use and increasing resistance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- antibiotic resistance
- competitive release
- ecology
- hygiene
- metacommunity ecology
Publication and Content Type
- art (subject category)
- ref (subject category)
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