Generation of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p.G2019S mutation in the LRRK2 gene

The leucine-rich repeat kinase 2 (LRRK2) p.G2019S mutation is the most common genetic cause of Parkinson's disease (PD). An induced pluripotent stem cell (iPSC) line CSC-41 was generated from a 75-year old patient diagnosed with PD caused by a p.G2019S mutation in LRRK2. Skin fibroblasts were reprogrammed using a non-integrating Sendai virus-based technology to deliver OCT3/4, SOX2, c-MYC and KLF4 transcription factors. The generated iPSC line exhibits expression of common pluripotency markers, differentiates into the three germ layers and has a normal karyotype. The iPSC line can be used to explore the association between LRRK2 mutation and PD.

Pomeshchik, YuriyLund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups(Swepub:lu)yu4617po (author)
Collin, AnnaLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-ada (author)
Goldwurm, StefanoIstituto Ortopedico Gaetano Pini (author)
Lamas, Nuno J.University of Minho(Swepub:lu)nu5731la (author)
Pinto, LuísaUniversity of Minho (author)
Salgado, António J.University of Minho (author)
Roybon, LaurentLund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups(Swepub:lu)mphy-lra (author)
University of MinhoStamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet (creator_code:org_t)

By the author/editor: Marote, Ana; Pomeshchik, Yuri ...; Collin, Anna; Goldwurm, Stefan ...; Lamas, Nuno J.; Pinto, Luísa; show more...; Salgado, António ...; Roybon, Laurent; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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