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Large Scale Identif...
Large Scale Identification of Variant Proteins in Glioma Stem Cells
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- Mostovenko, Ekaterina (author)
- Virginia Commonwealth University
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- Végvári, Ákos (author)
- Lund University,Lunds universitet,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Rezeli, Melinda (author)
- Lund University,Lunds universitet,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Lichti, Cheryl F. (author)
- Virginia Commonwealth University,Washington University in St. Louis
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- Fenyö, David (author)
- New York University
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- Wang, Qianghu (author)
- University of Texas
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- Lang, Frederick F. (author)
- University of Texas
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- Sulman, Erik P. (author)
- University of Texas
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- Sahlin, K. Barbara (author)
- Lund University,Lunds universitet,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Marko-Varga, György (author)
- Lund University,Lunds universitet,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Nilsson, Carol L. (author)
- Lund University,Lunds universitet,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 2017-12-21
- 2018
- English 7 s.
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In: ACS Chemical Neuroscience. - : American Chemical Society (ACS). - 1948-7193. ; 9:1, s. 73-79
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Abstract
Subject headings
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- Glioblastoma (GBM), the most malignant of primary brain tumors, is a devastating and deadly disease, with a median survival of 14 months from diagnosis, despite standard regimens of radical brain tumor surgery, maximal safe radiation, and concomitant chemotherapy. GBM tumors nearly always re-emerge after initial treatment and frequently display resistance to current treatments. One theory that may explain GBM re-emergence is the existence of glioma stemlike cells (GSCs). We sought to identify variant protein features expressed in low passage GSCs derived from patient tumors. To this end, we developed a proteomic database that reflected variant and nonvariant sequences in the human proteome, and applied a novel retrograde proteomic workflow, to identify and validate the expression of 126 protein variants in 33 glioma stem cell strains. These newly identified proteins may harbor a subset of novel protein targets for future development of GBM therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- bioinformatics
- GBM
- Glioblastoma
- parallel reaction monitoring
- precision medicine
- protein quantification
- protein single amino acid variants
- proteomics
- targeted mass spectrometry
- transcriptomics
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Mostovenko, Ekat ...
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Végvári, Ákos
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Rezeli, Melinda
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Lichti, Cheryl F ...
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Fenyö, David
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Wang, Qianghu
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show more...
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Lang, Frederick ...
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Sulman, Erik P.
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Sahlin, K. Barba ...
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Marko-Varga, Gyö ...
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Nilsson, Carol L ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medicinal Chemis ...
- Articles in the publication
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ACS Chemical Neu ...
- By the university
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Lund University