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Genetic susceptibil...
Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers
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Vineis, P. (author)
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Veglia, F. (author)
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Garte, S. (author)
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Malaveille, C. (author)
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Matullo, G. (author)
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Dunning, A. (author)
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Peluso, M. (author)
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Airoldi, L. (author)
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Overvad, K. (author)
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Raaschou-Nielsen, O. (author)
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Clavel-Chapelon, F. (author)
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Linseisen, J. P. (author)
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Kaaks, R. (author)
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Boeing, H. (author)
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Trichopoulou, A. (author)
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Palli, D. (author)
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Crosignani, P. (author)
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Tumino, R. (author)
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Panico, S. (author)
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Bueno-De-Mesquita, H. B. (author)
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Peeters, P. H. (author)
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Lund, E. (author)
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Gonzalez, C. A. (author)
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Martinez, C. (author)
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Dorronsor, M. (author)
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Barricarte, A. (author)
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Navarro, C. (author)
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Quiros, J. R. (author)
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- Berglund, Göran (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Jarvholm, B (author)
- Umeå universitet,Yrkes- och miljömedicin
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Day, N. E. (author)
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Key, T. J. (author)
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Saracci, R. (author)
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Riboli, E. (author)
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Autrup, H. (author)
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 18:7, s. 1230-1242
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase 11 metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). Results: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- bladder cancer
- metabolic genes
- lung cancer
- leukemia
- nonsmokers
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Vineis, P.
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Veglia, F.
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Garte, S.
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Malaveille, C.
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Matullo, G.
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Dunning, A.
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show more...
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Peluso, M.
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Airoldi, L.
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Overvad, K.
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Raaschou-Nielsen ...
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Clavel-Chapelon, ...
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Linseisen, J. P.
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Kaaks, R.
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Boeing, H.
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Trichopoulou, A.
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Palli, D.
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Crosignani, P.
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Tumino, R.
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Panico, S.
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Bueno-De-Mesquit ...
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Peeters, P. H.
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Lund, E.
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Gonzalez, C. A.
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Martinez, C.
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Dorronsor, M.
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Barricarte, A.
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Navarro, C.
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Quiros, J. R.
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Berglund, Göran
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Jarvholm, B
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Day, N. E.
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Key, T. J.
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Saracci, R.
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Riboli, E.
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Autrup, H.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Annals of Oncolo ...
- By the university
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Lund University
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Umeå University