Search: onr:"swepub:oai:lup.lub.lu.se:0eba5f86-2ab0-430d-823f-618d499e7b85" >
The Impact of Quadr...
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Wheeler, Cosette M.
(author)
The Impact of Quadrivalent Human Papillomavirus (HPV; Types 6, 11, 16, and 18) L1 Virus-Like Particle Vaccine on Infection and Disease Due to Oncogenic Nonvaccine HPV Types in Sexually Active Women Aged 16-26 Years
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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Oxford University Press (OUP),2009
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:0eba5f86-2ab0-430d-823f-618d499e7b85
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https://lup.lub.lu.se/record/1404742URI
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https://doi.org/10.1086/597309DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:118429424URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:kon swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background. We evaluated the impact of a quadrivalent human papillomavirus (HPV) vaccine on infection and cervical disease related to 10 nonvaccine HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) associated with >20% of cervical cancers. The population evaluated included HPV-naive women and women with preexisting HPV infection and/or HPV-related disease at enrollment. Methods. Phase 3 efficacy studies enrolled 17,622 women aged 16-26 years. Subjects underwent cervicovaginal sampling and Pap testing on day 1 and then at 6-12-month intervals for up to 4 years. HPV typing was performed on samples from enrollment and follow-up visits, including samples obtained for diagnosis or treatment of HPV-related disease. All subjects who received >= 1 dose and returned for follow-up were included. Results. Vaccination reduced the rate of HPV-31/33/45/52/58 infection by 17.7% (95% confidence interval [CI], 5.1% to 28.7%) and of cervical intraepithelial neoplasia (CIN) 1-3 or adenocarcinoma in situ (AIS) by 18.8% (95% CI, 7.4% to 28.9%). Vaccination also reduced the rate of HPV-31/58/59-related CIN1-3/AIS by 26.0% (95% CI, 6.7% to 41.4%), 28.1% (95% CI, 5.3% to 45.6%), and 37.6% (95% CI, 6.0% to 59.1%), respectively. Although a modest reduction in HPV-31/33/45/52/58-related CIN2 or worse was observed, the estimated reduction was not statistically significant. Conclusions. These cross-protection results complement the vaccine's prophylactic efficacy against disease associated with HPV-6, -11, -16, and - 18. Long-term monitoring of vaccinated populations are needed to fully ascertain the population-based impact and public health significance of these findings.
Subject headings and genre
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Kjaer, Susanne K.
(author)
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Sigurdsson, Kristjan
(author)
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Iversen, Ole-Erik
(author)
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Hernandez-Avila, Mauricio
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Perez, Gonzalo
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Brown, Darron R.
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Koutsky, Laura A.
(author)
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Tay, Eng Hseon
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Garcia, Patricia
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Ault, Kevin A.
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Garland, Suzanne M.
(author)
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Leodolter, Sepp
(author)
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Olsson, Sven-EricKarolinska Institutet
(author)
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Tang, Grace W. K.
(author)
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Ferris, Daron G.
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Paavonen, Jorma
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Steben, Marc
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Bosch, F. Xavier
(author)
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Dillner, JoakimKarolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)mikr-jdi
(author)
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Joura, Elmar A.
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Kurman, Robert J.
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Majewski, Slawomir
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Munoz, Nubia
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Myers, Evan R.
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Villa, Luisa L.
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Taddeo, Frank J.
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Roberts, Christine
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Tadesse, Amha
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Bryan, Janine
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Lupinacci, Lisa C.
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Giacoletti, Katherine E. D.
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James, Margaret
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Vuocolo, Scott
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Hesley, Teresa M.
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Barr, Eliav
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Karolinska InstitutetKlinisk mikrobiologi, Malmö
(creator_code:org_t)
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In:Journal Of Infectious Diseases: Oxford University Press (OUP)199:7, s. 936-9440022-18991537-6613
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Wheeler, Cosette ...
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Kjaer, Susanne K ...
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Sigurdsson, Kris ...
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Iversen, Ole-Eri ...
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Hernandez-Avila, ...
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Perez, Gonzalo
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Brown, Darron R.
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Koutsky, Laura A ...
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Tay, Eng Hseon
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Garcia, Patricia
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Ault, Kevin A.
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Garland, Suzanne ...
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Leodolter, Sepp
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Olsson, Sven-Eri ...
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Tang, Grace W. K ...
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Ferris, Daron G.
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Paavonen, Jorma
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Steben, Marc
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Bosch, F. Xavier
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Dillner, Joakim
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Joura, Elmar A.
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Kurman, Robert J ...
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Majewski, Slawom ...
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Munoz, Nubia
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Myers, Evan R.
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Villa, Luisa L.
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Taddeo, Frank J.
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Roberts, Christi ...
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Tadesse, Amha
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Bryan, Janine
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Lupinacci, Lisa ...
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Giacoletti, Kath ...
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James, Margaret
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Vuocolo, Scott
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Hesley, Teresa M ...
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Barr, Eliav
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- MEDICAL AND HEALTH SCIENCES
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Journal Of Infec ...
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Lund University
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Karolinska Institutet