Search: onr:"swepub:oai:lup.lub.lu.se:0f08da2d-65ee-479f-83dc-01400ddac941" >
Combined lifestyle ...
Combined lifestyle factors and the risk of LADA and type 2 diabetes – Results from a Swedish population-based case-control study
-
- Herzog, Katharina (author)
- Karolinska Institutet,Karolinska Institute
-
- Ahlqvist, Emma (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
-
- Alfredsson, Lars (author)
- Karolinska Institutet,Karolinska Institute
-
show more...
-
- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
-
- Hjort, Rebecka (author)
- Karolinska Institutet,Karolinska Institute
-
- Löfvenborg, Josefin E. (author)
- Karolinska Institutet,Karolinska Institute
-
- Tuomi, Tiinamaija (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM),University of Helsinki,Helsinki University Central Hospital
-
- Carlsson, Sofia (author)
- Karolinska Institutet,Karolinska Institute
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
-
In: Diabetes Research and Clinical Practice. - : Elsevier BV. - 0168-8227 .- 1872-8227. ; 174
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
http://www.diabetesr...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Aims: We investigated the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes in relation to a healthy lifestyle, the proportion of patients attributable to an unhealthy lifestyle, and the influence of family history of diabetes (FHD) and genetic susceptibility. Methods: The population-based study included incident LADA (n = 571), type 2 diabetes (n = 1962), and matched controls (n = 2217). A healthy lifestyle was defined by BMI < 25 kg/m2, moderate-to-high physical activity, a healthy diet, no smoking, and moderate alcohol consumption. We estimated odds ratios (OR) with 95% confidence intervals (CIs) adjusted for age, sex, education, and FHD. Results: Compared to a poor/moderate lifestyle, a healthy lifestyle was associated with a reduced risk of LADA (OR 0.51, CI 0.34–0.77) and type 2 diabetes (OR 0.09, CI 0.05–0.15). A healthy lifestyle conferred a reduced risk irrespective of FHD and high-risk HLA genotypes. Having a BMI < 25 kg/m2 conferred the largest risk reduction for both LADA (OR 0.54, CI 0.43–0.66) and type 2 diabetes (OR 0.12, CI 0.10–0.15) out of the individual items. Conclusion: People with a healthy lifestyle, especially a healthy body weight, have a reduced risk of LADA including those with genetic susceptibility to diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Autoimmune diabetes
- LADA
- Lifestyle
- Type 2 diabetes
- ANDIS
- diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database