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Surface-modified na...
Surface-modified nanoerythrosomes for potential optical imaging diagnostics
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- Fornasier, Marco (author)
- Center for Colloid and Surface Science (CSGI),University of Cagliari
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- Porcheddu, Andrea (author)
- University of Cagliari
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- Casu, Anna (author)
- AdventHealth
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- Raghavan, Srinivasa R. (author)
- University of Maryland
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- Jönsson, Peter (author)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Schillén, Karin (author)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Murgia, Sergio (author)
- Center for Colloid and Surface Science (CSGI),University of Cagliari
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English 8 s.
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In: Journal of Colloid and Interface Science. - : Elsevier BV. - 0021-9797. ; 582:Part A, s. 246-253
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Nanoerythrosomes (NERs), vesicle-like nanoparticles derived from red blood cells, represent a new and interesting vector for therapeutic molecules and imaging probes, mainly thanks to their high stability and excellent biocompatibility. Aiming to present a proof-of-concept of the use of NERs as diagnostic tools for in vitro/in vivo imaging purposes, we report here several functionalization routes to decorate the surfaces of NERs derived from bovine blood with two different fluorophores: 7-amino-4-methylcumarin and dibenzocyclooctinecyanine5.5. Notably, the fluorophores were cross-linked to the NERs surface with glutaraldehyde and, in the case of dibenzocyclooctinecyanine5.5, also using a click-chemistry route, termed strain-promoted azide-alkyne cycloaddition. The physicochemical characterization highlighted the high stability of the NERs derivatives in physiological conditions. Furthermore, the loading efficiency of the fluorophores on the NERs surface was evaluated using both UV–Vis spectroscopy and fluorescence microscopy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology -- Nano-technology (hsv//eng)
Keyword
- Cu-free click chemistry
- Fluorescence
- Ghosts
- Red blood cells
- Vesicles
Publication and Content Type
- art (subject category)
- ref (subject category)
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