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- Hall, ElinLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups (author)
Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- 2014-06-23
- Springer Science and Business Media LLC,2014
- electronicrdacarrier
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- LIBRIS-ID:oai:lup.lub.lu.se:0f9ff8c4-1a21-4b97-aaab-1935001d62e6
- https://lup.lub.lu.se/record/4527097URI
- https://doi.org/10.1186/1741-7015-12-103DOI
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- Language:English
- Summary in:English
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Notes
- Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Volkov, PetrLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)med-pvo (author)
- Dayeh, TasnimLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)med-tmd (author)
- Bacos, KarlLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)medk-kb0 (author)
- Rönn, TinaLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)med-tar (author)
- Dekker Nitert, MarloesLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)medk-mad (author)
- Ling, CharlotteLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)endo-cl0 (author)
- Diabetes - epigenetikForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:BMC Medicine: Springer Science and Business Media LLC12:11741-7015
Internet link
- https://portal.research.lu.se/files/3599438/5257208FULLTEXT
- http://www.ncbi.nlm.nih.gov/pubmed/24953961?dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1186/1741-7015-12-103FULLTEXT
- https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/1741-7015-12-103
- https://lup.lub.lu.se/record/4527097
- https://doi.org/10.1186/1741-7015-12-103
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