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Common Carotid Inti...
Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged
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Eikendal, Anouk L M (author)
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Groenewegen, Karlijn A (author)
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Anderson, Todd J (author)
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Britton, Annie R (author)
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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Evans, Greg W (author)
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de Graaf, Jacqueline (author)
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Grobbee, Diederick E (author)
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- Hedblad, Bo (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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Holewijn, Suzanne (author)
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Ikeda, Ai (author)
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Kitagawa, Kazuo (author)
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Kitamura, Akihiko (author)
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Lonn, Eva M (author)
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Lorenz, Matthias W (author)
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Mathiesen, Ellisiv B (author)
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Nijpels, Giel (author)
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Dekker, Jacqueline M (author)
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Okazaki, Shuhei (author)
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O'Leary, Daniel H (author)
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Polak, Joseph F (author)
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Price, Jacqueline F (author)
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Robertson, Christine (author)
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Rembold, Christopher M (author)
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- Rosvall, Maria (author)
- Lund University,Lunds universitet,Socialmedicin och hälsopolitik,Forskargrupper vid Lunds universitet,Social Medicine and Health Policy,Lund University Research Groups
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Rundek, Tatjana (author)
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Salonen, Jukka T (author)
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Sitzer, Matthias (author)
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Stehouwer, Coen D A (author)
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Hoefer, Imo E (author)
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Peters, Sanne A E (author)
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Bots, Michiel L (author)
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den Ruijter, Hester M (author)
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: Hypertension. - 1524-4563. ; 65:4, s. 707-707
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular disease at baseline, derived from 6 cohorts that are part of the USE-IMT initiative, an individual participant data meta-analysis of general-population-based cohort studies evaluating CIMT measurements. Information on risk factors, CIMT measurements, and follow-up of the combined end point (first-time myocardial infarction or stroke) was obtained. We assessed the relationship between risk factors and CIMT and the relationship between CIMT and first-time myocardial infarction or stroke using a multivariable linear mixed-effects model and a Cox proportional-hazards model, respectively. During a follow-up of 16.3 years, 55 first-time myocardial infarctions or strokes occurred. Median CIMT was 0.63 mm. Of the risk factors under study, age, sex, diastolic blood pressure, body mass index, total cholesterol, and high-density lipoprotein cholesterol related to CIMT. Furthermore, CIMT related to first-time myocardial infarction or stroke with a hazard ratio of 1.40 per SD increase in CIMT, independent of risk factors (95% confidence interval, 1.11-1.76). CIMT may be a valuable marker for cardiovascular risk in adults aged <45 years who are not yet eligible for standard cardiovascular risk screening. This is especially relevant in those with an increased, unfavor-able risk factor burden.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Eikendal, Anouk ...
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Groenewegen, Kar ...
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Anderson, Todd J
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Britton, Annie R
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Engström, Gunnar
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Evans, Greg W
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show more...
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de Graaf, Jacque ...
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Grobbee, Diederi ...
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Hedblad, Bo
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Holewijn, Suzann ...
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Ikeda, Ai
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Kitagawa, Kazuo
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Kitamura, Akihik ...
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Lonn, Eva M
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Lorenz, Matthias ...
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Mathiesen, Ellis ...
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Nijpels, Giel
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Dekker, Jacqueli ...
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Okazaki, Shuhei
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O'Leary, Daniel ...
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Polak, Joseph F
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Price, Jacquelin ...
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Robertson, Chris ...
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Rembold, Christo ...
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Rosvall, Maria
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Rundek, Tatjana
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Salonen, Jukka T
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Sitzer, Matthias
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Stehouwer, Coen ...
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Hoefer, Imo E
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Peters, Sanne A ...
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Bots, Michiel L
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den Ruijter, Hes ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Hypertension
- By the university
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Lund University