Search: onr:"swepub:oai:lup.lub.lu.se:0face793-571e-48df-989a-fb4a12491af2" >
Common Carotid Inti...
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Eikendal, Anouk L M
(author)
Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged
- Article/chapterEnglish2015
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LIBRIS-ID:oai:lup.lub.lu.se:0face793-571e-48df-989a-fb4a12491af2
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https://lup.lub.lu.se/record/5039563URI
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https://doi.org/10.1161/HYPERTENSIONAHA.114.04658DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular disease at baseline, derived from 6 cohorts that are part of the USE-IMT initiative, an individual participant data meta-analysis of general-population-based cohort studies evaluating CIMT measurements. Information on risk factors, CIMT measurements, and follow-up of the combined end point (first-time myocardial infarction or stroke) was obtained. We assessed the relationship between risk factors and CIMT and the relationship between CIMT and first-time myocardial infarction or stroke using a multivariable linear mixed-effects model and a Cox proportional-hazards model, respectively. During a follow-up of 16.3 years, 55 first-time myocardial infarctions or strokes occurred. Median CIMT was 0.63 mm. Of the risk factors under study, age, sex, diastolic blood pressure, body mass index, total cholesterol, and high-density lipoprotein cholesterol related to CIMT. Furthermore, CIMT related to first-time myocardial infarction or stroke with a hazard ratio of 1.40 per SD increase in CIMT, independent of risk factors (95% confidence interval, 1.11-1.76). CIMT may be a valuable marker for cardiovascular risk in adults aged <45 years who are not yet eligible for standard cardiovascular risk screening. This is especially relevant in those with an increased, unfavor-able risk factor burden.
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Groenewegen, Karlijn A
(author)
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Anderson, Todd J
(author)
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Britton, Annie R
(author)
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Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen
(author)
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Evans, Greg W
(author)
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de Graaf, Jacqueline
(author)
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Grobbee, Diederick E
(author)
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Hedblad, BoLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)medf-bhe
(author)
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Holewijn, Suzanne
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Ikeda, Ai
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Kitagawa, Kazuo
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Kitamura, Akihiko
(author)
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Lonn, Eva M
(author)
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Lorenz, Matthias W
(author)
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Mathiesen, Ellisiv B
(author)
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Nijpels, Giel
(author)
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Dekker, Jacqueline M
(author)
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Okazaki, Shuhei
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O'Leary, Daniel H
(author)
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Polak, Joseph F
(author)
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Price, Jacqueline F
(author)
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Robertson, Christine
(author)
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Rembold, Christopher M
(author)
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Rosvall, MariaLund University,Lunds universitet,Socialmedicin och hälsopolitik,Forskargrupper vid Lunds universitet,Social Medicine and Health Policy,Lund University Research Groups(Swepub:lu)smi-mro
(author)
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Rundek, Tatjana
(author)
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Salonen, Jukka T
(author)
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Sitzer, Matthias
(author)
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Stehouwer, Coen D A
(author)
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Hoefer, Imo E
(author)
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Peters, Sanne A E
(author)
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Bots, Michiel L
(author)
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den Ruijter, Hester M
(author)
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Kardiovaskulär forskning - epidemiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Hypertension65:4, s. 707-7071524-4563
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Eikendal, Anouk ...
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Groenewegen, Kar ...
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Anderson, Todd J
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Britton, Annie R
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Engström, Gunnar
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Evans, Greg W
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de Graaf, Jacque ...
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Grobbee, Diederi ...
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Hedblad, Bo
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Holewijn, Suzann ...
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Ikeda, Ai
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Kitagawa, Kazuo
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Kitamura, Akihik ...
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Lonn, Eva M
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Lorenz, Matthias ...
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Mathiesen, Ellis ...
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Nijpels, Giel
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Dekker, Jacqueli ...
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Okazaki, Shuhei
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O'Leary, Daniel ...
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Polak, Joseph F
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Price, Jacquelin ...
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Robertson, Chris ...
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Rembold, Christo ...
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Rosvall, Maria
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Rundek, Tatjana
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Salonen, Jukka T
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Sitzer, Matthias
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Stehouwer, Coen ...
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Hoefer, Imo E
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Peters, Sanne A ...
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Bots, Michiel L
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den Ruijter, Hes ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Hypertension
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Lund University