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A circular RNA gene...
A circular RNA generated from an intron of the insulin gene controls insulin secretion
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- Stoll, Lisa (author)
- Cornell University,University of Lausanne
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- Rodríguez-Trejo, Adriana (author)
- University of Lausanne
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- Guay, Claudiane (author)
- University of Lausanne
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- Brozzi, Flora (author)
- University of Lausanne
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- Bayazit, Mustafa Bilal (author)
- University of Lausanne
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- Gattesco, Sonia (author)
- University of Lausanne
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- Menoud, Véronique (author)
- University of Lausanne
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- Sobel, Jonathan (author)
- University of Lausanne
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- Marques, Ana Claudia (author)
- University of Lausanne
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- Venø, Morten Trillingsgaard (author)
- Aarhus University
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- Esguerra, Jonathan Lou S. (author)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
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- Barghouth, Mohammad (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
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- Suleiman, Mara (author)
- University of Pisa
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- Marselli, Lorella (author)
- University of Pisa
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- Kjems, Jørgen (author)
- Aarhus University
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- Eliasson, Lena (author)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
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- Renström, Erik (author)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Other operations, LTH,Faculty of Engineering, LTH,Diabetes - Islet Patophysiology,Lund University Research Groups
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- Bouzakri, Karim (author)
- University of Strasbourg
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- Pinget, Michel (author)
- University of Strasbourg
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- Marchetti, Piero (author)
- University of Pisa
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- Regazzi, Romano (author)
- University of Lausanne
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(creator_code:org_t)
- 2020-11-05
- 2020
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Abstract
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- Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose homeostasis. Here, we report that insulin secretion is regulated by a circular RNA containing the lariat sequence of the second intron of the insulin gene. Silencing of this intronic circular RNA in pancreatic islets leads to a decrease in the expression of key components of the secretory machinery of β-cells, resulting in impaired glucose- or KCl-induced insulin release and calcium signaling. The effect of the circular RNA is exerted at the transcriptional level and involves an interaction with the RNA-binding protein TAR DNA-binding protein 43 kDa (TDP-43). The level of this circularized intron is reduced in the islets of rodent diabetes models and of type 2 diabetic patients, possibly explaining their impaired secretory capacity. The study of this and other circular RNAs helps understanding β-cell dysfunction under diabetes conditions, and the etiology of this common metabolic disorder.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Stoll, Lisa
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Rodríguez-Trejo, ...
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Guay, Claudiane
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Brozzi, Flora
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Bayazit, Mustafa ...
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Gattesco, Sonia
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show more...
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Menoud, Véroniqu ...
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Sobel, Jonathan
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Marques, Ana Cla ...
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Venø, Morten Tri ...
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Esguerra, Jonath ...
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Barghouth, Moham ...
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Suleiman, Mara
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Marselli, Lorell ...
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Kjems, Jørgen
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Eliasson, Lena
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Renström, Erik
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Bouzakri, Karim
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Pinget, Michel
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Marchetti, Piero
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Regazzi, Romano
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University