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Atrial fibrillation...
Atrial fibrillation episode patterns as predictor of clinical outcome of catheter ablation
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- Saiz-Vivó, Javier (author)
- Polytechnic University of Milan,Medtronic Bakken Research Center, Maastricht
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- Corino, Valentina D.A. (author)
- Polytechnic University of Milan
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- Martín-Yebra, Alba (author)
- University of Zaragoza,CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)
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- Mainardi, Luca T. (author)
- Polytechnic University of Milan
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- Hatala, Robert (author)
- National Institute of Cardiovascular Diseases Slovakia
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- Sörnmo, Leif (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,LTH profilområde: Teknik för hälsa,LTH profilområden,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Engineering Health,LTH Profile areas,Faculty of Engineering, LTH
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(creator_code:org_t)
- 2022-11-21
- 2023
- English.
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In: Medical and Biological Engineering and Computing. - : Springer Science and Business Media LLC. - 0140-0118 .- 1741-0444. ; 61:2, s. 317-327
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Abstract
Subject headings
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- Methods for characterization of atrial fibrillation (AF) episode patterns have been introduced without establishing clinical significance. This study investigates, for the first time, whether post-ablation recurrence of AF can be predicted by evaluating episode patterns. The dataset comprises of 54 patients (age 56 ± 11 years; 67% men), with an implantable cardiac monitor, before undergoing the first AF catheter ablation. Two parameters of the alternating bivariate Hawkes model were used to characterize the pattern: AF dominance during the monitoring period (log(mu)) and temporal aggregation of episodes (beta1). Moreover, AF burden and AF density, a parameter characterizing aggregation of AF burden, were studied. The four parameters were computed from an average of 29 AF episodes before ablation. The risk of AF recurrence after catheter ablation using the Hawkes parameters log(mu) and beta1, AF burden, and AF density was evaluated. While the combination of AF burden and AF density is related to a non-significant hazard ratio, the combination of log(mu) and beta1 is related to a hazard ratio of 1.95 (1.03–3.70; p < 0.05). The Hawkes parameters showed increased risk of AF recurrence within 1 year after the procedure for patients with high AF dominance and high episode aggregation and may be used for pre-ablation risk assessment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Ablation
- AF burden
- Atrial fibrillation
- Recurrence
- Temporal aggregation
Publication and Content Type
- art (subject category)
- ref (subject category)
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