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HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma
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- Thuring, Camilla (author)
- Lund University,Lunds universitet,Antigen presentation,Forskargrupper vid Lunds universitet,Antigen Presentation,Lund University Research Groups,Lund Univ, Immunol Sect, Dept Expt Med Sci, SE-22184 Lund, Sweden.
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- Follin, Elna (author)
- Lund University,Lunds universitet,Antigen presentation,Forskargrupper vid Lunds universitet,Antigen Presentation,Lund University Research Groups,Lund Univ, Immunol Sect, Dept Expt Med Sci, SE-22184 Lund, Sweden.
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- Geironson Ulfsson, Linda (author)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Immunol Sect, Dept Expt Med Sci, SE-22184 Lund, Sweden.
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- (creator_code:org_t)
- 2015-08-27
- 2015
- English.
- In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 113:6, s. 952-962
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- HLA-I
- tapasin
- glioblastoma multiforme
- peptide
- tapasin-dependency
- immunotherapy
- tapasin
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Uppsala University
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