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Hyperinflammation a...
Hyperinflammation and Fibrosis in Severe COVID-19 Patients : Galectin-3, a Target Molecule to Consider
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- Garcia-Revilla, Juan (author)
- University Hospital Virgen del Rocío
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- Deierborg, Tomas (author)
- Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Venero, Jose Luis (author)
- University Hospital Virgen del Rocío
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- Boza-Serrano, Antonio (author)
- Lund University,Lunds universitet,Experimentell demensforskning,Forskargrupper vid Lunds universitet,Experimental Dementia Research,Lund University Research Groups,University Hospital Virgen del Rocío
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(creator_code:org_t)
- 2020-08-18
- 2020
- English.
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In: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 11
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Abstract
Subject headings
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- COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible and promising new therapeutical approach.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- biomarker
- COVID-19
- cytokine storm
- fibrosis
- galectin-3
Publication and Content Type
- art (subject category)
- ref (subject category)
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