Search: onr:"swepub:oai:lup.lub.lu.se:11e94b1d-0994-4543-980a-805429c583af" >
Reduction of Abeta ...
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
-
- Harach, T. (author)
- Swiss Federal Institute of Technology
-
- Marungruang, N. (author)
- Lund University,Lunds universitet,Centrum för preventiv livsmedelsforskning,Universitetets särskilda verksamheter,Food for Health Science Centre,University Specialised Centres
-
- Duthilleul, N. (author)
- Swiss Federal Institute of Technology
-
show more...
-
- Cheatham, V. (author)
- Swiss Federal Institute of Technology
-
- Mc Coy, K. D. (author)
- University of Bern
-
- Frisoni, G. B. (author)
- Geneva University Hospital,University of Geneva
-
- Neher, J. J. (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,University of Tübingen
-
- Fåk, F. (author)
- Lund University,Lunds universitet,Centrum för preventiv livsmedelsforskning,Universitetets särskilda verksamheter,Food for Health Science Centre,University Specialised Centres
-
- Jucker, Mathias (author)
- University of Tübingen,German Center for Neurodegenerative Diseases (DZNE), Bonn
-
- Lasser, Theo (author)
- Swiss Federal Institute of Technology
-
- Bolmont, T. (author)
- Swiss Federal Institute of Technology,Stemedica International
-
show less...
-
(creator_code:org_t)
- 2017-02-08
- 2017
- English.
-
In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://www.nature.c...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Alzheimer's disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number of brain disorders, its impact on Alzheimer's disease is not known. To this end we sequenced bacterial 16S rRNA from fecal samples of Aβ precursor protein (APP) transgenic mouse model and found a remarkable shift in the gut microbiota as compared to non-transgenic wild-type mice. Subsequently we generated germ-free APP transgenic mice and found a drastic reduction of cerebral Aβ amyloid pathology when compared to control mice with intestinal microbiota. Importantly, colonization of germ-free APP transgenic mice with microbiota from conventionally-raised APP transgenic mice increased cerebral Aβ pathology, while colonization with microbiota from wild-type mice was less effective in increasing cerebral Aβ levels. Our results indicate a microbial involvement in the development of Abeta amyloid pathology, and suggest that microbiota may contribute to the development of neurodegenerative diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Harach, T.
-
Marungruang, N.
-
Duthilleul, N.
-
Cheatham, V.
-
Mc Coy, K. D.
-
Frisoni, G. B.
-
show more...
-
Neher, J. J.
-
Fåk, F.
-
Jucker, Mathias
-
Lasser, Theo
-
Bolmont, T.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Scientific Repor ...
- By the university
-
Lund University