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Amphiregulin: Role ...
Amphiregulin: Role in mammary gland development and breast cancer
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McBryan, Jean (author)
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- Howlin, Jillian (author)
- Lund University,Lunds universitet,Experimentell patologi, Malmö,Forskargrupper vid Lunds universitet,Experimental Pathology, Malmö,Lund University Research Groups
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Napoletano, Silvia (author)
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Martin, Finian (author)
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(creator_code:org_t)
- 2008-04-09
- 2008
- English.
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In: Journal of Mammary Gland Biology and Neoplasia. - : Springer Science and Business Media LLC. - 1083-3021 .- 1573-7039. ; 13:2, s. 159-169
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Extensive epithelial cell proliferation underlies the ductal morphogenesis of puberty that generates the mammary tree that will eventually fill the fat pad. This estrogen-dependent process is believed to be essentially dependent on locally produced growth factors that act in a paracrine fashion. EGF-like growth factor ligands, acting through EGF receptors are some of the principal promoters of pubertal ductal morphogenesis. Amphiregulin is the most abundant EGF-like growth factor in the pubertal mammary gland. Its gene is transcriptionally regulated by ER alpha, and recent evidence identifies it as a key mediator of the estrogen-driven epithelial cell proliferation of puberty: The pubertal deficiency in mammary gland ductal morphogenesis in ER alpha, amphiregulin, and EGFR knockout mice phenocopy each other. As a prognostic indicator in human breast cancer, amphiregulin indicates an outcome identical to that predicted by ER alpha presence. Despite this, a range of studies both on preneoplastic human breast tissue and on cell culture based models of breast cancer, suggest a possibly significant role for amphiregulin in driving human breast cancer progression. Here we summarise our current understanding of amphiregulin's contribution to mammary gland development and breast cancer progression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- puberty
- amphiregulin
- estrogen
- ductal morphogenesis
Publication and Content Type
- art (subject category)
- ref (subject category)
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