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Psychiatric morbidi...
Psychiatric morbidity and its impact on surgical outcomes for esophageal and gastric cancer patients : A nationwide cohort study
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- Song, Huan (author)
- Karolinska Institutet
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- Zhu, Jianwei (author)
- Karolinska Institutet
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- Lu, Donghao (author)
- Karolinska Institutet
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- Fang, Fang (author)
- Karolinska Institutet
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- Ye, Weimin (author)
- Karolinska Institutet
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- Lundell, Lars (author)
- Karolinska Institutet
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- Johansson, Jan (author)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Upper Gastrointestinal Surgery,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Lindblad, Mats (author)
- Karolinska Institutet
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- Nilsson, Magnus (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2017-06-02
- 2017
- English 10 s.
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In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 8:46, s. 81305-81314
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Abstract
Subject headings
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- Background: Due to the lack of detailed clinical information, existed evidence regarding a link between psychiatric factors and adverse cancer prognosis was inclusive. Results: We identified 1,340 patients (48.8%) with perioperative psychiatric morbidity. Preoperative psychiatric morbidity was significantly associated with both general and surgical complications within 30 days (RR = 1.3, 95% confidence interval [CI] 1.1-1.5), and the risk of death within 90 days (RR = 1.6; 95% CI 1.1-2.2) after surgery. The hazards for mortality beyond 90 days was approximately 2-fold increased among patients with perioperative psychiatric morbidity (HR = 2.0, 95% CI 1.7-2.3 for overall mortality). Materials and Methods: Based on the Swedish National Registry for Esophageal and Gastric cancer (NREV), we constructed a nationwide prospective cohort containing 2,745 surgically treated patients in 2006-2012. Perioperative psychiatric morbidity was defined as a clinical diagnosis of psychiatric disorder, from two years before to two years after surgery. Using propensity scores, we applied inverse probability of treatment weights (IPTW)-weighted Poisson regression model to evaluate relative risk (RR) of short-term surgical outcomes in relation to perioperative psychiatric morbidity. Further, IPTW-weighted Cox proportional hazards model was used to estimate hazard ratios (HRs) for mortality that occurred after 90 days of surgery. Conclusions: Perioperative psychiatric morbidity could worsen both short-term and long-term surgical outcomes among patients with gastric or esophageal cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Esophageal cancer
- Gastric cancer
- Prognosis
- Psychiatric morbidity
- Surgery
Publication and Content Type
- art (subject category)
- ref (subject category)
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