Search: onr:"swepub:oai:lup.lub.lu.se:1316a7e3-b433-4920-8212-6a4d10135e76" > First infant formul...
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000 | 04805naa a2200541 4500 | |
001 | oai:lup.lub.lu.se:1316a7e3-b433-4920-8212-6a4d10135e76 | |
003 | SwePub | |
008 | 170616s2017 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/1316a7e3-b433-4920-8212-6a4d10135e762 URI |
024 | 7 | a https://doi.org/10.2337/dc16-16242 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Hummel, Sandrau Technical University of Munich4 aut |
245 | 1 0 | a First infant formula type and risk of islet autoimmunity in the environmental determinants of diabetes in the young (TEDDY) study |
264 | c 2017-01-17 | |
264 | 1 | b American Diabetes Association,c 2017 |
300 | a 7 s. | |
520 | a OBJECTIVE Studies on the introduction of infant formulas and its effect on the risk of islet autoimmunity and type 1 diabetes (T1D) have yielded inconsistent results. We investigated whether the introduction of formula based on hydrolyzed cow'smilk as the first formula is associated with reduced islet autoimmunity risk in a large prospective cohort. RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively monitors 8,676 children at increased genetic risk for T1D. Autoantibodies to insulin, GAD65, and IA2 were measured regularly to define islet autoimmunity. Information on formula feeding was collected by questionnaires at 3 months of age. RESULTS In survival analyses, after adjustment for family history with T1D, HLA genotype, sex, country, delivery mode, breast-feeding 3 months, and seasonality of birth, we observed no significant association with islet autoimmunity in infants who received extensively hydrolyzed compared with nonhydrolyzed cow'smilk-based formula as the first formula during the first 3 months (adjusted hazard ratio 1.38 [95% CI 0.95; 2.01]), and a significantly increased risk for extensively hydrolyzed formula introduced during the first 7 days (adjusted hazard ratio 1.57 [1.04; 2.38]). Using a partially hydrolyzed or other formula as the first formula, or no formula, was not associated with islet autoimmunity risk. CONCLUSIONS These results add to the existing evidence that islet autoimmunity risk is not reduced, and may be increased, by using hydrolyzed compared with nonhydrolyzed cow's milk-based infant formula as the first formula in infants at increased genetic risk for T1D . | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Beyerlein, Andreasu Technical University of Munich4 aut |
700 | 1 | a Tamura, Roy N.u University of South Florida4 aut |
700 | 1 | a Uusitalo, Ullau University of South Florida4 aut |
700 | 1 | a Andŕen Aronsson, Carinu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)smi-can |
700 | 1 | a Yang, Jiminu University of South Florida4 aut |
700 | 1 | a Riikonen, Anneu University of Tampere4 aut |
700 | 1 | a Lernmark, Akeu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ale |
700 | 1 | a Rewers, Marian J.u University of Colorado4 aut |
700 | 1 | a Hagopian, William A.u Pacific Northwest Research Institute4 aut |
700 | 1 | a She, Jin-Xiongu Medical College of Georgia4 aut |
700 | 1 | a Simell, Olli G.u Turku University Hospital4 aut |
700 | 1 | a Toppari, Jormau Turku University Hospital4 aut |
700 | 1 | a Ziegler, Anette-Gu Technical University of Munich4 aut |
700 | 1 | a Akolkar, Beena4 aut |
700 | 1 | a Krischer, Jeffrey P.u University of South Florida4 aut |
700 | 1 | a Virtanen, Suvi Mu University of Tampere4 aut |
700 | 1 | a Norris, Jill M4 aut |
710 | 2 | a Technical University of Munichb University of South Florida4 org |
773 | 0 | t Diabetes Cared : American Diabetes Associationg 40:3, s. 398-404q 40:3<398-404x 0149-5992x 1935-5548 |
856 | 4 | u http://dx.doi.org/10.2337/dc16-1624y FULLTEXT |
856 | 4 | u https://care.diabetesjournals.org/content/diacare/40/3/398.full.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/1316a7e3-b433-4920-8212-6a4d10135e76 |
856 | 4 8 | u https://doi.org/10.2337/dc16-1624 |
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