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Fetal and neonatal ...
Fetal and neonatal alloimmune thrombocytopenia.
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Zdravic, Darko (author)
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Yougbare, Issaka (author)
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Vadasz, Brian (author)
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Li, Conglei (author)
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Marshall, Alexandra H (author)
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Chen, Pingguo (author)
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- Kjeldsen-Kragh, Jens (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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Ni, Heyu (author)
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Seminars in Fetal & Neonatal Medicine. - : Elsevier BV. - 1878-0946 .- 1744-165X. ; 21:1, s. 19-27
- Related links:
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http://www.ncbi.nlm.... (free)
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is an alloimmune disorder resulting from platelet opsonization by maternal antibodies that destroy fetal platelets. The major risk of FNAIT is severe bleeding, particularly intracranial hemorrhage. Miscarriage has also been reported but the incidence requires further study. Analogous to adult autoimmune thrombocytopenia (ITP), the major target antigen in FNAIT is the platelet membrane glycoprotein (GP)IIbIIIa. FNAIT caused by antibodies against platelet GPIbα or other antigens has also been reported, but the reported incidence of the anti-GPIbα-mediated FNAIT is far lower than in ITP. To date, the maternal immune response to fetal platelet antigens is still not well understood and it is unclear why bleeding is more severe in FNAIT than in ITP. In this review, we introduce the pathogenesis of FNAIT, particularly those new discoveries from animal models, and discuss possible improvements for the diagnosis, therapy, and prevention of this devastating disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Antibody-induced immune suppression
- Fetal and neonatal alloimmune thrombocytopenia
- Intraveneous immunoglobulin G
- Platelets
Publication and Content Type
- for (subject category)
- ref (subject category)
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