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A quantitative Stre...
A quantitative Streptococcus pyogenes-human protein-protein interaction map reveals localization of opsonizing antibodies
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- Happonen, Lotta (author)
- Lund University,Lunds universitet,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Hauri, Simon (author)
- Lund University,Lunds universitet,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Svensson Birkedal, Gabriel (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Karlsson, Christofer (author)
- Lund University,Lunds universitet,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- de Neergaard, Therese (author)
- Lund University,Lunds universitet,Kvantitativ immunbiologi,Forskargrupper vid Lunds universitet,Quantitative immunobiology,Lund University Research Groups
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- Khakzad, Hamed (author)
- Swiss Institute for Bioinformatics (SIB),University of Zurich
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- Nordenfelt, Pontus (author)
- Lund University,Lunds universitet,Kvantitativ immunbiologi,Forskargrupper vid Lunds universitet,Quantitative immunobiology,Lund University Research Groups
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- Wikström, Mats (author)
- University of Copenhagen
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- Wisniewska, Magdalena (author)
- University of Copenhagen
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- Björck, Lars (author)
- Lund University,Lunds universitet,Molekylär patogenes,Forskargrupper vid Lunds universitet,Molecular Pathogenesis,Lund University Research Groups
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- Malmström, Lars (author)
- Lund University,Lunds universitet,epIgG,Forskargrupper vid Lunds universitet,Lund University Research Groups,Swiss Institute for Bioinformatics (SIB),University of Zurich
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- Malmström, Johan (author)
- Lund University,Lunds universitet,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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(creator_code:org_t)
- 2019-06-21
- 2019
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2727-2727
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Abstract
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- A fundamental challenge in medical microbiology is to characterize the dynamic protein-protein interaction networks formed at the host-pathogen interface. Here, we generate a quantitative interaction map between the significant human pathogen, Streptococcus pyogenes, and proteins from human saliva and plasma obtained via complementary affinity-purification and bacterial-surface centered enrichment strategies and quantitative mass spectrometry. Perturbation of the network using immunoglobulin protease cleavage, mixtures of different concentrations of saliva and plasma, and different S. pyogenes serotypes and their isogenic mutants, reveals how changing microenvironments alter the interconnectivity of the interaction map. The importance of host immunoglobulins for the interaction with human complement proteins is demonstrated and potential protective epitopes of importance for phagocytosis of S. pyogenes cells are localized. The interaction map confirms several previously described protein-protein interactions; however, it also reveals a multitude of additional interactions, with possible implications for host-pathogen interactions involving other bacterial species.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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- By the author/editor
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Happonen, Lotta
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Hauri, Simon
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Svensson Birkeda ...
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Karlsson, Christ ...
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de Neergaard, Th ...
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Khakzad, Hamed
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Nordenfelt, Pont ...
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Wikström, Mats
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Wisniewska, Magd ...
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Björck, Lars
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Malmström, Lars
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Malmström, Johan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Nature Communica ...
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Lund University