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E2F transcription f...
E2F transcription factors promote tumorigenicity in pancreatic ductal adenocarcinoma
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- Bertonnier-Brouty, Ludivine (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Endokrin Celldifferentiering,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Endocrine Cell Differentiation and Function
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- Andersson, Jonas (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups
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- Kaprio, Tuomas (author)
- Helsinki University Central Hospital,University of Helsinki
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- Hagström, Jaana (author)
- University of Helsinki,University of Turku,Helsinki University Central Hospital
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- Bsharat, Sara (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Endokrin Celldifferentiering,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Endocrine Cell Differentiation and Function
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- Asplund, Olof (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups
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- Hatem, Gad (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups
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- Haglund, Caj (author)
- Helsinki University Central Hospital,University of Helsinki
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- Seppänen, Hanna (author)
- University of Helsinki,Helsinki University Central Hospital
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- Prasad, Rashmi B (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups
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- Artner, Isabella (author)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Endokrin Celldifferentiering,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Endocrine Cell Differentiation and Function
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(creator_code:org_t)
- 2024
- 2024
- English 18 s.
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In: Cancer Medicine. - 2045-7634. ; 13:9
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with limited treatment options, illustrating an urgent need to identify new drugable targets in PDACs.OBJECTIVE: Using the similarities between tumor development and normal embryonic development, which is accompanied by rapid cell expansion, we aimed to identify and characterize embryonic signaling pathways that were reinitiated during tumor formation and expansion.METHODS AND RESULTS: Here, we report that the transcription factors E2F1 and E2F8 are potential key regulators in PDAC. E2F1 and E2F8 RNA expression is mainly localized in proliferating cells in the developing pancreas and in malignant ductal cells in PDAC. Silencing of E2F1 and E2F8 in PANC-1 pancreatic tumor cells inhibited cell proliferation and impaired cell spreading and migration. Moreover, loss of E2F1 also affected cell viability and apoptosis with E2F expression in PDAC tissues correlating with expression of apoptosis and mitosis pathway genes, suggesting that E2F factors promote cell cycle regulation and tumorigenesis in PDAC cells.CONCLUSION: Our findings illustrate that E2F1 and E2F8 transcription factors are expressed in pancreatic progenitor and PDAC cells, where they contribute to tumor cell expansion by regulation of cell proliferation, viability, and cell migration making these genes attractive therapeutic targets and potential prognostic markers for pancreatic cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Humans
- Carcinoma, Pancreatic Ductal/genetics
- Pancreatic Neoplasms/genetics
- Cell Proliferation
- E2F1 Transcription Factor/metabolism
- Cell Line, Tumor
- Cell Movement/genetics
- Apoptosis
- Gene Expression Regulation, Neoplastic
- Animals
- Repressor Proteins/genetics
- Cell Survival/genetics
- Mice
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Bertonnier-Brout ...
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Andersson, Jonas
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Kaprio, Tuomas
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Hagström, Jaana
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Bsharat, Sara
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Asplund, Olof
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show more...
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Hatem, Gad
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Haglund, Caj
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Seppänen, Hanna
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Prasad, Rashmi B
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Artner, Isabella
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cancer Medicine
- By the university
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Lund University