Meta-analysis identifies six new susceptibility loci for atrial fibrillation

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Ellinor, Patrick T. (author)

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

Article/chapterEnglish2012

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2012-04-29
Springer Science and Business Media LLC,2012

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LIBRIS-ID:oai:lup.lub.lu.se:13666abe-844c-465c-877e-0c7b0f3582c4
https://lup.lub.lu.se/record/2906770URI
https://doi.org/10.1038/ng.2261DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

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Lunetta, Kathryn L. (author)
Albert, Christine M. (author)
Glazer, Nicole L. (author)
Ritchie, Marylyn D. (author)
Smith, Albert V. (author)
Arking, Dan E. (author)
Mueller-Nurasyid, Martina (author)
Krijthe, Bouwe P. (author)
Lubitz, Steven A. (author)
Bis, Joshua C. (author)
Chung, Mina K. (author)
Doerr, Marcus (author)
Ozaki, Kouichi (author)
Roberts, Jason D. (author)
Smith, GustavLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)med-gvs (author)
Pfeufer, Arne (author)
Sinner, Moritz F. (author)
Lohman, Kurt (author)
Ding, Jingzhong (author)
Smith, Nicholas L. (author)
Smith, Jonathan D. (author)
Rienstra, Michiel (author)
Rice, Kenneth M. (author)
Van Wagoner, David R. (author)
Magnani, Jared W. (author)
Wakili, Reza (author)
Clauss, Sebastian (author)
Rotter, Jerome I. (author)
Steinbeck, Gerhard (author)
Launer, Lenore J. (author)
Davies, Robert W. (author)
Borkovich, Matthew (author)
Harris, Tamara B. (author)
Lin, Honghuang (author)
Voelker, Uwe (author)
Voelzke, Henry (author)
Milan, David J. (author)
Hofman, Albert (author)
Boerwinkle, Eric (author)
Chen, Lin Y. (author)
Soliman, Elsayed Z. (author)
Voight, Benjamin F. (author)
Li, Guo (author)
Chakravarti, Aravinda (author)
Kubo, Michiaki (author)
Tedrow, Usha B. (author)
Rose, Lynda M. (author)
Ridker, Paul M. (author)
Conen, David (author)
Tsunoda, Tatsuhiko (author)
Furukawa, Tetsushi (author)
Sotoodehnia, Nona (author)
Xu, Siyan (author)
Kamatani, Naoyuki (author)
Levy, Daniel (author)
Nakamura, Yusuke (author)
Parvez, Babar (author)
Mahida, Saagar (author)
Furie, Karen L. (author)
Rosand, Jonathan (author)
Muhammad, Raafia (author)
Psaty, Bruce M. (author)
Meitinger, Thomas (author)
Perz, Siegfried (author)
Wichmann, H-Erich (author)
Witteman, Jacqueline C. M. (author)
Kao, W. H. Linda (author)
Kathiresan, Sekar (author)
Roden, Dan M. (author)
Uitterlinden, Andre G. (author)
Rivadeneira, Fernando (author)
McKnight, Barbara (author)
Sjögren, MarketaLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-msj (author)
Newman, Anne B. (author)
Liu, Yongmei (author)
Gollob, Michael H. (author)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
Tanaka, Toshihiro (author)
Stricker, Bruno H. Ch (author)
Felix, Stephan B. (author)
Alonso, Alvaro (author)
Darbar, Dawood (author)
Barnard, John (author)
Chasman, Daniel I. (author)
Heckbert, Susan R. (author)
Benjamin, Emelia J. (author)
Gudnason, Vilmundur (author)
Kaeaeb, Stefan (author)
Kardiovaskulär forskning - hypertoniForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC44:6, s. 88-6701546-17181061-4036

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By the author/editor: Ellinor, Patrick ...; Lunetta, Kathryn ...; Albert, Christin ...; Glazer, Nicole L ...; Ritchie, Marylyn ...; Smith, Albert V.; show more...; Arking, Dan E.; Mueller-Nurasyid ...; Krijthe, Bouwe P ...; Lubitz, Steven A ...; Bis, Joshua C.; Chung, Mina K.; Doerr, Marcus; Ozaki, Kouichi; Roberts, Jason D ...; Smith, Gustav; Pfeufer, Arne; Sinner, Moritz F ...; Lohman, Kurt; Ding, Jingzhong; Smith, Nicholas ...; Smith, Jonathan ...; Rienstra, Michie ...; Rice, Kenneth M.; Van Wagoner, Dav ...; Magnani, Jared W ...; Wakili, Reza; Clauss, Sebastia ...; Rotter, Jerome I ...; Steinbeck, Gerha ...; Launer, Lenore J ...; Davies, Robert W ...; Borkovich, Matth ...; Harris, Tamara B ...; Lin, Honghuang; Voelker, Uwe; Voelzke, Henry; Milan, David J.; Hofman, Albert; Boerwinkle, Eric; Chen, Lin Y.; Soliman, Elsayed ...; Voight, Benjamin ...; Li, Guo; Chakravarti, Ara ...; Kubo, Michiaki; Tedrow, Usha B.; Rose, Lynda M.; Ridker, Paul M.; Conen, David; Tsunoda, Tatsuhi ...; Furukawa, Tetsus ...; Sotoodehnia, Non ...; Xu, Siyan; Kamatani, Naoyuk ...; Levy, Daniel; Nakamura, Yusuke; Parvez, Babar; Mahida, Saagar; Furie, Karen L.; Rosand, Jonathan; Muhammad, Raafia; Psaty, Bruce M.; Meitinger, Thoma ...; Perz, Siegfried; Wichmann, H-Eric ...; Witteman, Jacque ...; Kao, W. H. Linda; Kathiresan, Seka ...; Roden, Dan M.; Uitterlinden, An ...; Rivadeneira, Fer ...; McKnight, Barbar ...; Sjögren, Marketa; Newman, Anne B.; Liu, Yongmei; Gollob, Michael ...; Melander, Olle; Tanaka, Toshihir ...; Stricker, Bruno ...; Felix, Stephan B ...; Alonso, Alvaro; Darbar, Dawood; Barnard, John; Chasman, Daniel ...; Heckbert, Susan ...; Benjamin, Emelia ...; Gudnason, Vilmun ...; Kaeaeb, Stefan; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: Nature Genetics

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