Search: onr:"swepub:oai:lup.lub.lu.se:140625d3-f0be-4f00-9533-792f7807d55a" >
The proportion of c...
-
Obrant, KarlLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
(author)
The proportion of carboxylated to total or intact osteocalcin in serum discriminates warfarin-treated patients from control subjects
- Article/chapterEnglish1999
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:140625d3-f0be-4f00-9533-792f7807d55a
-
https://lup.lub.lu.se/record/1114957URI
-
https://doi.org/10.1359/jbmr.1999.14.4.555DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
We assessed the serum concentration of gamma-carboxylated osteocalcin (OC), total OC, and full-length OC in a clinical setting of 37 patients on continuous warfarin treatment (international normalized ratio 2.0-3.8). A comparison was done with the results from 30 untreated age-matched controls. Four monoclonal antibodies, previously generated and characterized as to their ability to recognize different human OC forms and fragments, were used in three two-site immunofluorometric assays. The warfarin-treated patients had significantly lower levels of carboxylated OC 4.9 +/- 3.8 (+/- 1 SD) ng/ml compared with the controls 13.1 +/- 9.7 (p < 0.0001). There was no difference in the levels of total OC or full-length OC between the two groups of patients. A strong correlation was found between the serum concentration of carboxylated OC and total OC, both for the warfarin-treated patients (r = 0.98) and for the controls (r = 0.99). There was a distinct cut-off level at 0.80, in the quotient carboxylated OC/total OC, at which all warfarin-treated patients fell below and all controls above this level. Hence, the concentration or ratio of serum gamma-carboxylated OC in clinical settings such as warfarin-treated patients could be measured using two-site immunoassays.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Kakonen, S M
(author)
-
Astermark, JanLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)medf-jas
(author)
-
Lilja, HansLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-hli
(author)
-
Lovgren, T
(author)
-
Åkesson, KristinaLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-kak
(author)
-
Pettersson, K
(author)
-
Ortopedi - klinisk och molekylär osteoporosforskningForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:Journal of Bone and Mineral Research: Wiley14:4, s. 555-5601523-46810884-0431
Internet link
Find in a library
To the university's database