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Impact of Cernitin™...
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Chabot, SophieUrosphere
(author)
Impact of Cernitin™ on induced chronic prostatitis in animal model for understanding management of lower urinary tract symptoms
- Article/chapterEnglish2021
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LIBRIS-ID:oai:lup.lub.lu.se:1491eb3a-d705-497f-a03c-619b41f16540
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https://lup.lub.lu.se/record/1491eb3a-d705-497f-a03c-619b41f16540URI
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https://doi.org/10.1016/j.phyplu.2021.100057DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: Cernitin™ pollen extracts (brand name Cernilton®) alleviates symptoms related to common lower uro-genital tract disorders in men. The underlying mechanisms are ill-defined but the inflammatory pathway could be one of them. In a previous in vitro study it was shown that Cernitin™ induce a regulatory effect on inflammatory parameters. Methods: In this study, male Sprague Dawley rats were used to validate the effects of Cernitin™ in chronic prostatitis and benign prostatic hyperplasia. Pain was assessed by von Frey assay. Results: Cernitin™ exhibited significant pain relief in the induced prostatitis rat model and was associated with a significant decrease in the intraprostatic level of COX-2 and MCP-1 in the prostatic tissue homogenates. In a parallel study, Cernitin™ treatment led to a significant decrease in prostate weight in rats with testosterone induced BPH. Concurrently, a significant decrease in the percentage of proliferation marker, Ki-67, and androgen receptor expressing cells was observed. Similarly, a low level of cytoplasmic 5α-reductase expression was observed in Cernitin™- and finasteride-treated animals. Conclusion: The current in vivo experiments support the use of Cernitin™ as an anti-inflammatory and symptom reducing agent that could, in part, explain the impact of Cernitin™ on the management of chronic pelvic pain in men.
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Dizeyi, NishtmanLund University,Lunds universitet,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Urological research, Malmö,Lund University Research Groups,AB Cernelle(Swepub:lu)kir-dni
(author)
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Ramnemark, LenaAB Cernelle
(author)
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Lluel, PhilippeUrosphere
(author)
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Abrahamsson, Per AndersLund University,Lunds universitet,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Urological research, Malmö,Lund University Research Groups,AB Cernelle(Swepub:lu)uro-paa
(author)
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Grabe, MagnusLund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups(Swepub:lu)kir-mgr
(author)
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UrosphereUrologi, Malmö (Abrahamsson)
(creator_code:org_t)
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In:Phytomedicine Plus: Elsevier BV1:42667-0313
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