Association of infant Rib and Alp1 surface protein N-terminal domain immunoglobulin G and invasive Group B Streptococcal disease in young infants

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Dangor, ZiyaadUniversity of the Witwatersrand (author)

Association of infant Rib and Alp1 surface protein N-terminal domain immunoglobulin G and invasive Group B Streptococcal disease in young infants

Article/chapterEnglish2023

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Elsevier BV,2023
5 s.

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LIBRIS-ID:oai:lup.lub.lu.se:14cab3d1-06cb-44aa-8856-faa4c8c9f917
https://lup.lub.lu.se/record/14cab3d1-06cb-44aa-8856-faa4c8c9f917URI
https://doi.org/10.1016/j.vaccine.2023.01.071DOI

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Language:English
Summary in:English

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Background: Vaccine development for Group B Streptococcus (GBS), a common cause of invasive disease in early-infancy and adverse pregnancy outcomes, include exploring widely-expressed GBS surface proteins as vaccine epitopes. We investigated the association between natural infant serum IgG against the RibN and Alp1N domains and risk of invasive GBS disease caused by isolates expressing these proteins. Methods: We analyzed maternal and infant serum samples from GBS disease cases and infants born to GBS-colonized women controls. Bayesian modelling was used to calculate the GBS homotypic IgG concentration associated with risk reduction of invasive disease in the infant. Results: PCR-based typing of 85 GBS invasive isolates showed 46 and 24 possessing the gene for Rib and Alp1, respectively. These were matched to 46 and 36 infant controls whose mothers were colonized with GBS expressing Rib and Alp1, respectively. RibN IgG geometric mean concentrations (GMC) were lower in cases than controls among infants (0.01; 95 %CI: 0.01–0.02 vs 0.04; 95 %CI: 0.03–0.06; p < 0.001), no significant difference was found between maternal RibN IgG GMC in cases compared to controls. Alp1N IgG GMC was also lower in infant cases (0.02; 95 %CI: 0.01–0.03) than controls (0.05; 95 %CI: 0.04–0.07; p < 0.001); albeit not so in mothers. An infant IgG threshold ≥ 0.428 and ≥ 0.112 µg/mL was associated with 90 % risk reduction of invasive GBS disease due to Rib and Alp1 expressing strains, respectively. Discussion: Lower serum RibN and Alp1N IgG GMC were evident in infants with invasive GBS disease compared with controls born to women colonized with GBS expressing the homotypic protein. These data support the evaluation of Alp family proteins as potential vaccine candidates against invasive GBS disease.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
Alp family proteins
Correlate
GBS vaccine
Immune responses

Added entries (persons, corporate bodies, meetings, titles ...)

Kwatra, GauravUniversity of the Witwatersrand,Christian Medical College & Hospital (author)
Pawlowski, AndrzejLund University,Lunds universitet,Adaptivt immunförsvar,Forskargrupper vid Lunds universitet,Adaptive Immunity,Lund University Research Groups(Swepub:lu)med-apw (author)
Fisher, Per B.MinervaX ApS (author)
Izu, AlaneUniversity of the Witwatersrand (author)
Lala, Sanjay G.University of the Witwatersrand (author)
Johansson-Lindbom, BengtLund University,Lunds universitet,Adaptivt immunförsvar,Forskargrupper vid Lunds universitet,Adaptive Immunity,Lund University Research Groups,MinervaX ApS(Swepub:lu)immt-bjo (author)
Madhi, Shabir A.University of the Witwatersrand (author)
University of the WitwatersrandChristian Medical College & Hospital (creator_code:org_t)

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In:Vaccine: Elsevier BV41:10, s. 1679-16830264-410X

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By the author/editor: Dangor, Ziyaad; Kwatra, Gaurav; Pawlowski, Andrz ...; Fisher, Per B.; Izu, Alane; Lala, Sanjay G.; show more...; Johansson-Lindbo ...; Madhi, Shabir A.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

Articles in the publication: Vaccine

By the university: Lund University

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