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Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
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- Wang, Xue Jing (author)
- First Affiliated Hospital of Zhengzhou University
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- Ma, Ming Ming (author)
- First Affiliated Hospital of Zhengzhou University
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- Zhou, Le Bo (author)
- First Affiliated Hospital of Zhengzhou University
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- (creator_code:org_t)
- 2020-02-18
- 2020
- English.
- In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
- Journal article (peer-reviewed)
Abstract
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- α-Synucleinopathies are characterized by autonomic dysfunction and motor impairments. In the pure autonomic failure (PAF), α-synuclein (α-Syn) pathology is confined within the autonomic nervous system with no motor features, but mouse models recapitulating PAF without motor dysfunction are lacking. Here, we show that in TgM83+/− mice, inoculation of α-Syn preformed fibrils (PFFs) into the stellate and celiac ganglia induces spreading of α-Syn pathology only through the autonomic pathway to both the central nervous system (CNS) and the autonomic innervation of peripheral organs bidirectionally. In parallel, the mice develop autonomic dysfunction, featured by orthostatic hypotension, constipation, hypohidrosis and hyposmia, without motor dysfunction. Thus, we have generated a mouse model of pure autonomic dysfunction caused by α-Syn pathology. This model may help define the mechanistic link between transmission of pathological α-Syn and the cardinal features of autonomic dysfunction in α-synucleinopathy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- Wang, Xue Jing
- Ma, Ming Ming
- Zhou, Le Bo
- Jiang, Xiao Yi
- Hao, Miao Miao
- Teng, Robert K.F ...
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- Wu, Erxi
- Tang, Bei Sha
- Li, Jia Yi
- Teng, Jun Fang
- Ding, Xue Bing
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- MEDICAL AND HEALTH SCIENCES
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- Lund University
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