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Modeling of C/EBP a...
Modeling of C/EBP alpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells
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Kirstetter, Peggy (author)
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Schuster, Mikkel B. (author)
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Bereshchenko, Oksana (author)
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Moore, Susan (author)
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Dvinge, Heidi (author)
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Kurz, Elke (author)
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Theilgaard-Monch, Kim (author)
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- Månsson, Robert (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Pedersen, Thomas A. (author)
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Pabst, Thomas (author)
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Schrock, Evelin (author)
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Porse, Bo T. (author)
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- Jacobsen, Sten Eirik W (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Bertone, Paul (author)
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Tenen, Daniel G. (author)
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Nerlov, Claus (author)
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
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In: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 13:4, s. 299-310
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Abstract
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- Mutations in the CEBPA gene are present in 7%-10% of human patients with acute myeloid leukemia (AML). However, no genetic models exist that demonstrate their etiological relevance. To mimic the most common mutations affecting CEBPA-that is, those leading to loss of the 42 kDa C/EBP alpha isoform (p42) while retaining the 30kDa isoform (p30)-we modified the mouse Cebpa locus to express only p30. p30 supported the formation of granulocyte-macrophage progenitors. However, p42 was required for control of myeloid progenitor proliferation, and p42-deficient mice developed AML with complete penetrance. p42-deficient leukemia could be transferred by a Mac1(+)c-Kit(+) population that gave rise only to myeloid cells in recipient mice. Expression profiling of this population against normal Mac1(+)c-Kit(+) progenitors revealed a signature shared with MLL-AF9-transformed AML.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Kirstetter, Pegg ...
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Schuster, Mikkel ...
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Bereshchenko, Ok ...
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Moore, Susan
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Dvinge, Heidi
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Kurz, Elke
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show more...
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Theilgaard-Monch ...
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Månsson, Robert
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Pedersen, Thomas ...
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Pabst, Thomas
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Schrock, Evelin
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Porse, Bo T.
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Jacobsen, Sten E ...
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Bertone, Paul
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Tenen, Daniel G.
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Nerlov, Claus
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Cell
- By the university
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Lund University