Anti-beta 2 glycoprotein I IgA in the SLICC classification criteria dataset

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Fältnamn	Indikatorer	Metadata
000		06682naa a2200841 4500
001		oai:lup.lub.lu.se:16987df5-29de-4712-a7c3-3b6d9494b540
003		SwePub
008		210528s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/16987df5-29de-4712-a7c3-3b6d9494b5402 URI
024	7	a https://doi.org/10.1177/096120332110142482 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Elkhalifa, Marwau Johns Hopkins University School of Medicine,Alexandria University4 aut
245	1 0	a Anti-beta 2 glycoprotein I IgA in the SLICC classification criteria dataset
264		c 2021-05-06
264	1	b SAGE Publications,c 2021
300		a 6 s.
520		a Objective: Anti-beta 2 glycoprotein I IgA is a common isotype of anti-beta 2 glycoprotein I in SLE. Anti-beta 2 glycoprotein I was not included in the American College of Rheumatology (ACR) SLE classification criteria, but was included in the Systemic Lupus International Collaborating Clinics (SLICC) criteria. We aimed to evaluate the prevalence of anti-beta 2-glycoprotein I IgA in SLE versus other rheumatic diseases. In addition, we examined the association between anti-beta 2 glycoprotein I IgA and disease manifestations in SLE. Methods: The dataset consisted of 1384 patients, 657 with a consensus physician diagnosis of SLE and 727 controls with other rheumatic diseases. Anti-beta 2 glycoprotein I isotypes were measured by ELISA. Patients with a consensus diagnosis of SLE were compared to controls with respect to presence of anti-beta 2 glycoprotein I. Among patients with SLE, we assessed the association between anti-beta 2 glycoprotein I IgA and clinical manifestations. Results: The prevalence of anti-beta 2 glycoprotein I IgA was 14% in SLE patients and 7% in rheumatic disease controls (odds ratio, OR 2.3, 95% CI: 1.6, 3.3). It was more common in SLE patients who were younger patients and of African descent (p = 0.019). Eleven percent of SLE patients had anti-beta 2 glycoprotein I IgA alone (no anti-beta 2 glycoprotein I IgG or IgM). There was a significant association between anti-beta 2 glycoprotein I IgA and anti-dsDNA (p = 0.001) and the other antiphospholipid antibodies (p = 0.0004). There was no significant correlation of anti-beta 2 glycoprotein I IgA with any of the other ACR or SLICC clinical criteria for SLE. Those with anti-beta 2 glycoprotein I IgA tended to have a history of thrombosis (12% vs 6%, p = 0.071), but the difference was not statistically significant. Conclusion: We found the anti-beta 2 glycoprotein I IgA isotype to be more common in patients with SLE and in particular, with African descent. It could occur alone without other isotypes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653		a anti-beta 2 glycoprotein IgA
653		a antiphospholipid antibodies
653		a classification criteria
653		a Systemic lupus erythematosus
700	1	a Orbai, Ana Mariau Johns Hopkins University School of Medicine4 aut
700	1	a Magder, Laurence S.u University of Maryland School of Medicine4 aut
700	1	a Petri, Michelleu Johns Hopkins University School of Medicine4 aut
700	1	a Alarcón, Graciela S.u University of Alabama4 aut
700	1	a Gordon, Carolineu University of Birmingham4 aut
700	1	a Merrill, Joanu Oklahoma Medical Research Foundation4 aut
700	1	a Fortin, Paul R.u Laval University4 aut
700	1	a Bruce, Ian N.4 aut
700	1	a Isenberg, Davidu University College London4 aut
700	1	a Wallace, Danielu University of California, Los Angeles4 aut
700	1	a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-oni
700	1	a Ramsey-Goldman, Rosalindu Northwestern University Feinberg School of Medicine4 aut
700	1	a Bae, Sang Cheolu Hanyang University4 aut
700	1	a Hanly, John G.u Dalhousie University4 aut
700	1	a Sanchez-Guerrero, Jorgeu University of Toronto4 aut
700	1	a Clarke, Ann E.4 aut
700	1	a Aranow, Cynthiau Feinstein Institute for Medical Research4 aut
700	1	a Manzi, Susanu Allegheny Health Network4 aut
700	1	a Urowitz, Murrayu University of Toronto4 aut
700	1	a Gladman, Dafna D.u University of Toronto4 aut
700	1	a Kalunian, Kenu University of California, San Diego4 aut
700	1	a Werth, Victoria P.u Hospital of the University of Pennsylvania4 aut
700	1	a Zoma, Asadu Hairmyres Hospital4 aut
700	1	a Bernatsky, Sashau McGill University Health Center4 aut
700	1	a Khamashta, Munther4 aut
700	1	a Jacobsen, SØrenu Copenhagen University Hospital4 aut
700	1	a Buyon, Jill P.u New York University4 aut
700	1	a Dooley, Mary Anneu University of North Carolina4 aut
700	1	a Vollenhoven, Ronald vanu Academic Medical Center of University of Amsterdam (AMC),Vrije Universiteit Amsterdam4 aut
700	1	a Ginzler, Ellenu SUNY Downstate Health Sciences University4 aut
700	1	a Stoll, Thomasu Cantonal Hospital of Olten4 aut
700	1	a Peschken, Christineu University of Manitoba4 aut
700	1	a Jorizzo, Joseph L.u Weill Cornell Medical College4 aut
700	1	a Callen, Jeffery P.u University of Louisville Health Sciences Center4 aut
700	1	a Lim, Samu Emory University4 aut
700	1	a Inanc, Murat4 aut
700	1	a Kamen, Diane L.u Medical University of South Carolina4 aut
700	1	a Rahman, Anisuru University College London4 aut
700	1	a Steinsson, Kristjanu National University Hospital of Iceland4 aut
700	1	a Franks, Andrew G.u New York University4 aut
710	2	a Johns Hopkins University School of Medicineb Alexandria University4 org
773	0	t Lupusd : SAGE Publicationsg 30:8, s. 1283-1288q 30:8<1283-1288x 0961-2033x 1477-0962
856	4	u http://dx.doi.org/10.1177/09612033211014248y FULLTEXT
856	4	u https://discovery.ucl.ac.uk/10131180/3/Isenberg_Anti-beta%202%20glycoprotein%20I%20IgA%20in%20the%20SLICC%20classification%20criteria%20dataset_AAM.pdf
856	4 8	u https://lup.lub.lu.se/record/16987df5-29de-4712-a7c3-3b6d9494b540
856	4 8	u https://doi.org/10.1177/09612033211014248

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Rheumatology and ...

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