Search: onr:"swepub:oai:lup.lub.lu.se:1707e5e8-3681-4994-ab58-bc512e1738af" >
The landscape of vi...
The landscape of viral associations in human cancers
-
- Zapatka, Marc (author)
- German Cancer Research Centre
-
- Borozan, Ivan (author)
- Ontario Institute for Cancer Research
-
- Brewer, Daniel S (author)
- University of East Anglia
-
show more...
-
- Iskar, Murat (author)
- German Cancer Research Centre
-
- Grundhoff, Adam (author)
- Heinrich Pette Institut
-
- Alawi, Malik (author)
- Heinrich Pette Institut
-
- Desai, Nikita (author)
- University College London Hospital
-
- Sültmann, Holger (author)
- National Centre of Tumor Diseases,German Cancer Research Centre
-
- Moch, Holger (author)
- University Hospital of Zurich
-
- Cooper, Colin S (author)
- Earlham Institute
-
- Eils, Roland (author)
- German Cancer Research Centre
-
- Ferretti, Vincent (author)
- Ontario Institute for Cancer Research
-
- Lichter, Peter (author)
- German Cancer Research Centre
-
- Borg, Åke (creator_code:cre_t)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
-
- Ringnér, Markus (creator_code:cre_t)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science
-
- Staaf, Johan (creator_code:cre_t)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund
-
show less...
-
(creator_code:org_t)
-
-
show more...
-
-
show less...
- 2020-02-05
- 2020
- English.
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 52:3, s. 320-330
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://www.nature.c...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and-for a subset-whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential viral pathogens using a consensus approach that integrated three independent pipelines. Viruses were detected in 382 genome and 68 transcriptome datasets. We found a high prevalence of known tumor-associated viruses such as Epstein-Barr virus (EBV), hepatitis B virus (HBV) and human papilloma virus (HPV; for example, HPV16 or HPV18). The study revealed significant exclusivity of HPV and driver mutations in head-and-neck cancer and the association of HPV with APOBEC mutational signatures, which suggests that impaired antiviral defense is a driving force in cervical, bladder and head-and-neck carcinoma. For HBV, HPV16, HPV18 and adeno-associated virus-2 (AAV2), viral integration was associated with local variations in genomic copy numbers. Integrations at the TERT promoter were associated with high telomerase expression evidently activating this tumor-driving process. High levels of endogenous retrovirus (ERV1) expression were linked to a worse survival outcome in patients with kidney cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- DNA Copy Number Variations
- DNA Tumor Viruses/genetics
- Genome, Human/genetics
- Hepatitis B virus/genetics
- Herpesvirus 4, Human/genetics
- Humans
- Mutation
- Neoplasms/genetics
- Papillomavirus Infections/genetics
- Promoter Regions, Genetic/genetics
- Telomerase/genetics
- Transcriptome
- Tumor Virus Infections/virology
- Virus Integration
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Zapatka, Marc
-
Borozan, Ivan
-
Brewer, Daniel S
-
Iskar, Murat
-
Grundhoff, Adam
-
Alawi, Malik
-
show more...
-
Desai, Nikita
-
Sültmann, Holger
-
Moch, Holger
-
Cooper, Colin S
-
Eils, Roland
-
Ferretti, Vincen ...
-
Lichter, Peter
-
Borg, Åke
-
Ringnér, Markus
-
Staaf, Johan
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Nature Genetics
- By the university
-
Lund University
-
Karolinska Institutet