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  • Zapatka, MarcGerman Cancer Research Centre (author)

The landscape of viral associations in human cancers

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-02-05
  • Springer Science and Business Media LLC,2020

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:1707e5e8-3681-4994-ab58-bc512e1738af
  • https://lup.lub.lu.se/record/1707e5e8-3681-4994-ab58-bc512e1738afURI
  • https://doi.org/10.1038/s41588-019-0558-9DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:142904541URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and-for a subset-whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential viral pathogens using a consensus approach that integrated three independent pipelines. Viruses were detected in 382 genome and 68 transcriptome datasets. We found a high prevalence of known tumor-associated viruses such as Epstein-Barr virus (EBV), hepatitis B virus (HBV) and human papilloma virus (HPV; for example, HPV16 or HPV18). The study revealed significant exclusivity of HPV and driver mutations in head-and-neck cancer and the association of HPV with APOBEC mutational signatures, which suggests that impaired antiviral defense is a driving force in cervical, bladder and head-and-neck carcinoma. For HBV, HPV16, HPV18 and adeno-associated virus-2 (AAV2), viral integration was associated with local variations in genomic copy numbers. Integrations at the TERT promoter were associated with high telomerase expression evidently activating this tumor-driving process. High levels of endogenous retrovirus (ERV1) expression were linked to a worse survival outcome in patients with kidney cancer.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Borozan, IvanOntario Institute for Cancer Research (author)
  • Brewer, Daniel SUniversity of East Anglia (author)
  • Iskar, MuratGerman Cancer Research Centre (author)
  • Grundhoff, AdamHeinrich Pette Institut (author)
  • Alawi, MalikHeinrich Pette Institut (author)
  • Desai, NikitaUniversity College London Hospital (author)
  • Sültmann, HolgerNational Centre of Tumor Diseases,German Cancer Research Centre (author)
  • Moch, HolgerUniversity Hospital of Zurich (author)
  • Cooper, Colin SEarlham Institute (author)
  • Eils, RolandGerman Cancer Research Centre (author)
  • Ferretti, VincentOntario Institute for Cancer Research (author)
  • Lichter, PeterGerman Cancer Research Centre (author)
  • Borg, ÅkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-abo (creator_code:cre_t)
  • Ringnér, MarkusLund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science(Swepub:lu)thep-mri (creator_code:cre_t)
  • Staaf, JohanLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund(Swepub:lu)onk-jst (creator_code:cre_t)
  • German Cancer Research CentreOntario Institute for Cancer Research (creator_code:org_t)
  • PCAWG Pathogens
  • PCAWG Consortium

Related titles

  • In:Nature Genetics: Springer Science and Business Media LLC52:3, s. 320-3301546-17181061-4036

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