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Characterization of...
Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease–related blood-based biomarkers : Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group
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- Verberk, Inge M.W. (author)
- Vrije Universiteit Amsterdam
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- Misdorp, Els O. (author)
- Vrije Universiteit Amsterdam
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- Koelewijn, Jannet (author)
- Vrije Universiteit Amsterdam
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- Ball, Andrew J. (author)
- Quanterix Corporation
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- Blennow, Kaj (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Dage, Jeffrey L. (author)
- Eli Lilly and Company
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Fandos, Noelia (author)
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Hirtz, Christophe (author)
- University of Montpellier
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- Janelidze, Shorena (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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Kang, Sungmin (author)
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Kirmess, Kristopher (author)
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- Kindermans, Jana (author)
- University of Montpellier
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Lee, Ryan (author)
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Meyer, Matthew R. (author)
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- Shan, Dandan (author)
- Quanterix Corporation
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- Shaw, Leslie M. (author)
- University of Pennsylvania
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- Waligorska, Teresa (author)
- University of Pennsylvania
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- West, Tim (author)
- C2N Diagnostics
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- Zetterberg, Henrik (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,University College London,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Edelmayer, Rebecca M. (author)
- Alzheimer's Association: Alzheimer's Disease and Dementia
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- Teunissen, Charlotte E. (author)
- Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2021-11-29
- 2022
- English.
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 18:8, s. 1484-1497
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Abstract
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- Introduction: Pre-analytical sample handling might affect the results of Alzheimer's disease blood-based biomarkers. We empirically tested variations of common blood collection and handling procedures. Methods: We created sample sets that address the effect of blood collection tube type, and of ethylene diamine tetraacetic acid plasma delayed centrifugation, centrifugation temperature, aliquot volume, delayed storage, and freeze–thawing. We measured amyloid beta (Aβ)42 and 40 peptides with six assays, and Aβ oligomerization-tendency (OAβ), amyloid precursor protein (APP)699-711, glial fibrillary acidic protein (GFAP), neurofilament light (NfL), total tau (t-tau), and phosphorylated tau181. Results: Collection tube type resulted in different values of all assessed markers. Delayed plasma centrifugation and storage affected Aβ and t-tau; t-tau was additionally affected by centrifugation temperature. The other markers were resistant to handling variations. Discussion: We constructed a standardized operating procedure for plasma handling, to facilitate introduction of blood-based biomarkers into the research and clinical settings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- amyloid beta
- plasma biomarkers
- pre-analytics
- stability
- tau
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Verberk, Inge M. ...
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Misdorp, Els O.
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Koelewijn, Janne ...
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Ball, Andrew J.
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Blennow, Kaj
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Dage, Jeffrey L.
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show more...
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Fandos, Noelia
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Hansson, Oskar
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Hirtz, Christoph ...
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Janelidze, Shore ...
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Kang, Sungmin
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Kirmess, Kristop ...
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Kindermans, Jana
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Lee, Ryan
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Meyer, Matthew R ...
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Shan, Dandan
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Shaw, Leslie M.
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Waligorska, Tere ...
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West, Tim
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Zetterberg, Henr ...
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Edelmayer, Rebec ...
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Teunissen, Charl ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University
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University of Gothenburg